Next Article in Journal
The Role of Topoisomerase II in DNA Repair and Recombination in Arabidopsis thaliana
Previous Article in Journal
Protocadherin-7 Regulates Osteoclast Differentiation through Intracellular SET-Binding Domain-Mediated RhoA and Rac1 Activation
Article

Identified Three Interferon Induced Proteins as Novel Biomarkers of Human Ischemic Cardiomyopathy

1
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
2
University of Chinese Academy of Sciences, Beijing 100049, China
3
School of Life Sciences, Yunnan University, Kunming 650091, China
4
School of Chemical Science & Technology, Yunnan University, Kunming 650091, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Marialessandra Contino
Int. J. Mol. Sci. 2021, 22(23), 13116; https://doi.org/10.3390/ijms222313116
Received: 5 October 2021 / Revised: 11 November 2021 / Accepted: 15 November 2021 / Published: 4 December 2021
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Ischemic cardiomyopathy is the most frequent type of heart disease, and it is a major cause of myocardial infarction (MI) and heart failure (HF), both of which require expensive medical treatment. Precise biomarkers and therapy targets must be developed to enhance improve diagnosis and treatment. In this study, the transcriptional profiles of 313 patients’ left ventricle biopsies were obtained from the PubMed database, and functional genes that were significantly related to ischemic cardiomyopathy were screened using the Weighted Gene Co-Expression Network Analysis and protein–protein interaction (PPI) networks enrichment analysis. The rat myocardial infarction model was developed to validate these findings. Finally, the putative signature genes were blasted through the common Cardiovascular Disease Knowledge Portal to explore if they were associated with cardiovascular disorder. Three interferon stimulated genes (IFIT2, IFIT3 and IFI44L), as well as key pathways, have been identified as potential biomarkers and therapeutic targets for ischemic cardiomyopathy, and their alternations or mutations have been proven to be strongly linked to cardiac disorders. These novel signature genes could be utilized as bio-markers or potential therapeutic objectives in precise clinical diagnosis and treatment of ischemic cardiomyopathy. View Full-Text
Keywords: ischemic cardiomyopathy; heart failure; WGCNA; interferon stimulated genes; IFIT2/3 ischemic cardiomyopathy; heart failure; WGCNA; interferon stimulated genes; IFIT2/3
Show Figures

Figure 1

MDPI and ACS Style

Chen, C.; Tian, J.; He, Z.; Xiong, W.; He, Y.; Liu, S. Identified Three Interferon Induced Proteins as Novel Biomarkers of Human Ischemic Cardiomyopathy. Int. J. Mol. Sci. 2021, 22, 13116. https://doi.org/10.3390/ijms222313116

AMA Style

Chen C, Tian J, He Z, Xiong W, He Y, Liu S. Identified Three Interferon Induced Proteins as Novel Biomarkers of Human Ischemic Cardiomyopathy. International Journal of Molecular Sciences. 2021; 22(23):13116. https://doi.org/10.3390/ijms222313116

Chicago/Turabian Style

Chen, Cheng, Jiao Tian, Zhicheng He, Wenyong Xiong, Yingying He, and Shubai Liu. 2021. "Identified Three Interferon Induced Proteins as Novel Biomarkers of Human Ischemic Cardiomyopathy" International Journal of Molecular Sciences 22, no. 23: 13116. https://doi.org/10.3390/ijms222313116

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop