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Article

Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain

A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok 690041, Russia
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Author to whom correspondence should be addressed.
Academic Editors: Bae Hwan Lee, Hee Young Kim and Hee Kee Kim
Int. J. Mol. Sci. 2021, 22(23), 12779; https://doi.org/10.3390/ijms222312779
Received: 2 November 2021 / Revised: 24 November 2021 / Accepted: 24 November 2021 / Published: 26 November 2021
(This article belongs to the Special Issue Neuro-Plastic Mechanisms of Pain and Addiction)
Neuropathic pain arises from damage or dysfunction of the peripheral or central nervous system and manifests itself in a wide variety of sensory symptoms and cognitive disorders. Many studies demonstrate the role of neuropathic pain-induced neuroinflammation in behavioral disorders. For effective neuropathic pain treatment, an integrative approach is required, which simultaneously affects several links of pathogenesis. One promising candidate for this role is synaptamide (N-docosahexaenoylethanolamine), which is an endogenous metabolite of docosahexaenoic acid. In this study, we investigated the activity of synaptamide on mice behavior and hippocampal plasticity in neuropathic pain induced by spared nerve injury (SNI). We found a beneficial effect of synaptamide on the thermal allodynia and mechanical hyperalgesia dynamics. Synaptamide prevented working and long-term memory impairment. These results are probably based on the supportive effect of synaptamide on SNI-impaired hippocampal plasticity. Nerve ligation caused microglia activation predominantly in the contralateral hippocampus, while synaptamide inhibited this effect. The treatment reversed dendritic tree degeneration, dendritic spines density reduction on CA1-pyramidal neurons, neurogenesis deterioration, and hippocampal long-term potentiation (LTP) impairment. In addition, synaptamide inhibits changes in the glutamatergic receptor expression. Thus, synaptamide has a beneficial effect on hippocampal functioning, including synaptic plasticity and hippocampus-dependent cognitive processes in neuropathic pain. View Full-Text
Keywords: synaptamide; N-docosahexaenoylethanolamine; neuropathic pain; spared nerve injury; hippocampus; neuroinflammation synaptamide; N-docosahexaenoylethanolamine; neuropathic pain; spared nerve injury; hippocampus; neuroinflammation
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MDPI and ACS Style

Tyrtyshnaia, A.; Bondar, A.; Konovalova, S.; Manzhulo, I. Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain. Int. J. Mol. Sci. 2021, 22, 12779. https://doi.org/10.3390/ijms222312779

AMA Style

Tyrtyshnaia A, Bondar A, Konovalova S, Manzhulo I. Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain. International Journal of Molecular Sciences. 2021; 22(23):12779. https://doi.org/10.3390/ijms222312779

Chicago/Turabian Style

Tyrtyshnaia, Anna, Anatoly Bondar, Sophia Konovalova, and Igor Manzhulo. 2021. "Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain" International Journal of Molecular Sciences 22, no. 23: 12779. https://doi.org/10.3390/ijms222312779

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