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Early-Pregnancy Dydrogesterone Supplementation Mimicking Luteal-Phase Support in ART Patients Did Not Provoke Major Reproductive Disorders in Pregnant Mice and Their Progeny
Review

Key to Life: Physiological Role and Clinical Implications of Progesterone

1
National Laboratory for Human Reproduction, University of Pécs, 7624 Pécs, Hungary
2
Department of Obstetrics and Gynecology, Medical School, University of Pécs, 7624 Pécs, Hungary
3
MTA-PTE Human Reproduction Scientific Research Group, University of Pécs, 7624 Pécs, Hungary
4
Szentágothai Research Center, University of Pécs, 7624 Pécs, Hungary
5
Department of Medical Biology, Medical School, University of Pécs, 7624 Pécs, Hungary
6
Department of Laboratory Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary
7
Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, 7624 Pécs, Hungary
*
Author to whom correspondence should be addressed.
These authors share senior authorship.
Academic Editor: Muriel Le Romancer
Int. J. Mol. Sci. 2021, 22(20), 11039; https://doi.org/10.3390/ijms222011039
Received: 9 September 2021 / Revised: 10 October 2021 / Accepted: 11 October 2021 / Published: 13 October 2021
The most recent studies of progesterone research provide remarkable insights into the physiological role and clinical importance of this hormone. Although the name progesterone itself means “promoting gestation”, this steroid hormone is far more than a gestational agent. Progesterone is recognized as a key physiological component of not only the menstrual cycle and pregnancy but also as an essential steroidogenic precursor of other gonadal and non-gonadal hormones such as aldosterone, cortisol, estradiol, and testosterone. Based on current findings, progesterone and novel progesterone-based drugs have many important functions, including contraception, treatment of dysfunctional uterine bleeding, immune response, and prevention of cancer. Considering the above, reproduction and life are not possible without progesterone; thus, a better understanding of this essential molecule could enable safe and effective use of this hormone in many clinical conditions. View Full-Text
Keywords: progesterone; progestogens; progestins; steroid; in vitro fertilization (IVF); intracytoplasmic sperm injection (ICSI) progesterone; progestogens; progestins; steroid; in vitro fertilization (IVF); intracytoplasmic sperm injection (ICSI)
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MDPI and ACS Style

Nagy, B.; Szekeres-Barthó, J.; Kovács, G.L.; Sulyok, E.; Farkas, B.; Várnagy, Á.; Vértes, V.; Kovács, K.; Bódis, J. Key to Life: Physiological Role and Clinical Implications of Progesterone. Int. J. Mol. Sci. 2021, 22, 11039. https://doi.org/10.3390/ijms222011039

AMA Style

Nagy B, Szekeres-Barthó J, Kovács GL, Sulyok E, Farkas B, Várnagy Á, Vértes V, Kovács K, Bódis J. Key to Life: Physiological Role and Clinical Implications of Progesterone. International Journal of Molecular Sciences. 2021; 22(20):11039. https://doi.org/10.3390/ijms222011039

Chicago/Turabian Style

Nagy, Bernadett, Júlia Szekeres-Barthó, Gábor L. Kovács, Endre Sulyok, Bálint Farkas, Ákos Várnagy, Viola Vértes, Kálmán Kovács, and József Bódis. 2021. "Key to Life: Physiological Role and Clinical Implications of Progesterone" International Journal of Molecular Sciences 22, no. 20: 11039. https://doi.org/10.3390/ijms222011039

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