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Article

Aggregation Properties of Albumin in Interacting with Magnetic Fluids

by
Elena N. Velichko
1,*,
Elina K. Nepomnyashchaya
1,*,
Maksim A. Baranov
1,*,
Alexey N. Skvortsov
2,
Ivan V. Pleshakov
3 and
Ge Dong
4,*
1
Institute of Electronics and Telecommunications, Peter the Great St. Petersburg Polytechnic University, 195251 Saint Petersburg, Russia
2
Institute of Biomedical Systems and Biotechnology, Peter the Great St. Petersburg Polytechnic University, 195251 Saint Petersburg, Russia
3
Ioffe Institute, 194021 Saint Petersburg, Russia
4
School of Aerospace Engineering, Tsinghua University, Beijing 100084, China
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(19), 10734; https://doi.org/10.3390/ijms221910734
Submission received: 20 September 2021 / Revised: 27 September 2021 / Accepted: 29 September 2021 / Published: 3 October 2021
(This article belongs to the Special Issue Structure, Energy, and Dynamics of Molecular Interactions)
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Abstract

In this study, interactions of Fe3O4 magnetic nanoparticles with serum albumin biomolecules in aqueous solutions were considered. The studies were conducted with the laser correlation spectroscopy and optical analysis of dehydrated films. It was shown that the addition of magnetite to an albumin solution at low concentrations of up to 10−6 g/L led to the formation of aggregates with sizes of up to 300 nm in the liquid phase and an increase in the number of spiral structures in the dehydrated films, which indicated an increase in their stability. With a further increase in the magnetite concentration in the solution (from 10−4 g/L), the magnetic particles stuck together and to albumin, thus forming aggregates with sizes larger than 1000 nm. At the same time, the formation of morphological structures in molecular films was disturbed, and a characteristic decrease in their stability occurred. Most stable films were formed at low concentrations of magnetic nanoparticles (less than 10−4 g/L) when small albumin–magnetic nanoparticle aggregates were formed. These results are important for characterizing the interaction processes of biomolecules with magnetic nanoparticles and can be useful for predicting the stability of biomolecular films with the inclusion of magnetite particles.
Keywords: protein–nanoparticle interaction; molecular electronics; magnetic fluid; self-organization; nanoparticle sizing; dynamic light scattering protein–nanoparticle interaction; molecular electronics; magnetic fluid; self-organization; nanoparticle sizing; dynamic light scattering

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MDPI and ACS Style

Velichko, E.N.; Nepomnyashchaya, E.K.; Baranov, M.A.; Skvortsov, A.N.; Pleshakov, I.V.; Dong, G. Aggregation Properties of Albumin in Interacting with Magnetic Fluids. Int. J. Mol. Sci. 2021, 22, 10734. https://doi.org/10.3390/ijms221910734

AMA Style

Velichko EN, Nepomnyashchaya EK, Baranov MA, Skvortsov AN, Pleshakov IV, Dong G. Aggregation Properties of Albumin in Interacting with Magnetic Fluids. International Journal of Molecular Sciences. 2021; 22(19):10734. https://doi.org/10.3390/ijms221910734

Chicago/Turabian Style

Velichko, Elena N., Elina K. Nepomnyashchaya, Maksim A. Baranov, Alexey N. Skvortsov, Ivan V. Pleshakov, and Ge Dong. 2021. "Aggregation Properties of Albumin in Interacting with Magnetic Fluids" International Journal of Molecular Sciences 22, no. 19: 10734. https://doi.org/10.3390/ijms221910734

APA Style

Velichko, E. N., Nepomnyashchaya, E. K., Baranov, M. A., Skvortsov, A. N., Pleshakov, I. V., & Dong, G. (2021). Aggregation Properties of Albumin in Interacting with Magnetic Fluids. International Journal of Molecular Sciences, 22(19), 10734. https://doi.org/10.3390/ijms221910734

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