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Volume 22
Issue 19
10.3390/ijms221910702
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Article

Simulated Microgravity Inhibits Rodent Dermal Fibroblastic Differentiation of Mesenchymal Stem Cells by Suppressing ERK/β-Catenin Signaling Pathway

by
Yansiwei Cheng
,
Yuhao Zhou
,
Wenjun Lv
,
Qing Luo
* and
Guanbin Song
*
Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(19), 10702; https://doi.org/10.3390/ijms221910702
Submission received: 30 August 2021 / Revised: 29 September 2021 / Accepted: 29 September 2021 / Published: 2 October 2021
(This article belongs to the Special Issue Recent Advances in Microgravity and Cell Adherence)
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Abstract

Studies have shown that bone marrow-derived mesenchymal stem cells (BMSCs) can differentiate into dermal fibroblasts to participate in skin-repairing. However, at present, little is known about how microgravity affects dermal fibroblastic differentiation of BMSCs in space. The aim of this study was to investigate the effect of simulated microgravity (SMG) on the differentiation of BMSCs into dermal fibroblasts and the related molecular mechanism. Here, using a 2D-clinostat device to simulate microgravity, we found that SMG inhibited the differentiation and suppressed the Wnt/β-catenin signaling and phosphorylation of extracellular regulated protein kinases 1/2 (ERK1/2). After upregulating the Wnt/β-catenin signaling with lithium chloride (LiCl) treatment, we found that the effect of the differentiation was restored. Moreover, the Wnt/β-catenin signaling was upregulated when phosphorylation of ERK1/2 was activated with tert-Butylhydroquinone (tBHQ) treatment. Taken together, our findings suggest that SMG inhibits dermal fibroblastic differentiation of BMSCs by suppressing ERK/β-catenin signaling pathway, inferring that ERK/β-catenin signaling pathway may act as a potential intervention target for repairing skin injury under microgravity conditions.
Keywords: simulated microgravity; mesenchymal stem cells; fibroblastic differentiation; space medicine; skin-repairing simulated microgravity; mesenchymal stem cells; fibroblastic differentiation; space medicine; skin-repairing

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MDPI and ACS Style

Cheng, Y.; Zhou, Y.; Lv, W.; Luo, Q.; Song, G. Simulated Microgravity Inhibits Rodent Dermal Fibroblastic Differentiation of Mesenchymal Stem Cells by Suppressing ERK/β-Catenin Signaling Pathway. Int. J. Mol. Sci. 2021, 22, 10702. https://doi.org/10.3390/ijms221910702

AMA Style

Cheng Y, Zhou Y, Lv W, Luo Q, Song G. Simulated Microgravity Inhibits Rodent Dermal Fibroblastic Differentiation of Mesenchymal Stem Cells by Suppressing ERK/β-Catenin Signaling Pathway. International Journal of Molecular Sciences. 2021; 22(19):10702. https://doi.org/10.3390/ijms221910702

Chicago/Turabian Style

Cheng, Yansiwei, Yuhao Zhou, Wenjun Lv, Qing Luo, and Guanbin Song. 2021. "Simulated Microgravity Inhibits Rodent Dermal Fibroblastic Differentiation of Mesenchymal Stem Cells by Suppressing ERK/β-Catenin Signaling Pathway" International Journal of Molecular Sciences 22, no. 19: 10702. https://doi.org/10.3390/ijms221910702

APA Style

Cheng, Y., Zhou, Y., Lv, W., Luo, Q., & Song, G. (2021). Simulated Microgravity Inhibits Rodent Dermal Fibroblastic Differentiation of Mesenchymal Stem Cells by Suppressing ERK/β-Catenin Signaling Pathway. International Journal of Molecular Sciences, 22(19), 10702. https://doi.org/10.3390/ijms221910702

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