Effects of Substitution on Cytotoxicity of Diphenyl Ditelluride in Cultured Vascular Endothelial Cells
Abstract
:1. Introduction
2. Results
2.1. Diphenyl Ditelluride (DPDTe) Accumulates and Exhibits Cytotoxicity in Vascular Endothelial Cells and Fibroblastic IMR-90 Cells
2.2. Cleavage of Te–Te Bond Is Important for Accumulation and Cytotoxicity of DPDTe
2.3. Substitution Modulate Cytotoxicity of DPDTe
3. Discussion
4. Materials and Methods
4.1. Materials
4.2. Cell Culture and Treatments
4.3. Cytotoxicity Assay and Cell Viability Assay
4.4. Intracellular Accumulation of Organotellurium and Organoselenium Compounds
4.5. Ab Initio Quantum Chemical Calculation
4.6. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Hara, T.; Okazaki, T.; Hashiya, T.; Nozawa, K.; Yasuike, S.; Kurita, J.; Yamamoto, C.; Hamada, N.; Kaji, T. Effects of Substitution on Cytotoxicity of Diphenyl Ditelluride in Cultured Vascular Endothelial Cells. Int. J. Mol. Sci. 2021, 22, 10520. https://doi.org/10.3390/ijms221910520
Hara T, Okazaki T, Hashiya T, Nozawa K, Yasuike S, Kurita J, Yamamoto C, Hamada N, Kaji T. Effects of Substitution on Cytotoxicity of Diphenyl Ditelluride in Cultured Vascular Endothelial Cells. International Journal of Molecular Sciences. 2021; 22(19):10520. https://doi.org/10.3390/ijms221910520
Chicago/Turabian StyleHara, Takato, Takahiro Okazaki, Tamayo Hashiya, Kyohei Nozawa, Shuji Yasuike, Jyoji Kurita, Chika Yamamoto, Noriaki Hamada, and Toshiyuki Kaji. 2021. "Effects of Substitution on Cytotoxicity of Diphenyl Ditelluride in Cultured Vascular Endothelial Cells" International Journal of Molecular Sciences 22, no. 19: 10520. https://doi.org/10.3390/ijms221910520