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Review

Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances

Department of Biomedical Sciences, Section of Neurosciences and Clinical Pharmacology, University of Cagliari, 09124 Cagliari, Italy
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Academic Editor: Kerstin Uvnäs-Moberg
Int. J. Mol. Sci. 2021, 22(19), 10376; https://doi.org/10.3390/ijms221910376
Received: 9 September 2021 / Revised: 20 September 2021 / Accepted: 23 September 2021 / Published: 26 September 2021
(This article belongs to the Special Issue Advances in Oxytocin)
A continuously increasing amount of research shows that oxytocin is involved in numerous central functions. Among the functions in which oxytocin is thought to be involved are those that play a role in social and sexual behaviors, and the involvement of central oxytocin in erectile function and sexual behavior was indeed one of the first to be discovered in laboratory animals in the 1980s. The first part of this review summarizes the results of studies done in laboratory animals that support a facilitatory role of oxytocin in male and female sexual behavior and reveal mechanisms through which this ancient neuropeptide participates in concert with other neurotransmitters and neuropeptides in this complex function, which is fundamental for the species reproduction. The second part summarizes the results of studies done mainly with intranasal oxytocin in men and women with the aim to translate the results found in laboratory animals to humans. Unexpectedly, the results of these studies do not appear to confirm the facilitatory role of oxytocin found in male and female sexual behavior in animals, both in men and women. Possible explanations for the failure of oxytocin to improve sexual behavior in men and women and strategies to attempt to overcome this impasse are considered. View Full-Text
Keywords: oxytocin; erectile function; sexual behavior oxytocin; erectile function; sexual behavior
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MDPI and ACS Style

Melis, M.R.; Argiolas, A. Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances. Int. J. Mol. Sci. 2021, 22, 10376. https://doi.org/10.3390/ijms221910376

AMA Style

Melis MR, Argiolas A. Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances. International Journal of Molecular Sciences. 2021; 22(19):10376. https://doi.org/10.3390/ijms221910376

Chicago/Turabian Style

Melis, Maria Rosaria, and Antonio Argiolas. 2021. "Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances" International Journal of Molecular Sciences 22, no. 19: 10376. https://doi.org/10.3390/ijms221910376

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