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Review

A Disintegrin and Metalloproteinase (ADAM) Family: Their Significance in Malignant Tumors of the Central Nervous System (CNS)

1
Department of Biochemical Diagnostics, Medical University, 15-269 Bialystok, Poland
2
Department of Neurodegeneration Diagnostics, Medical University, 15-269 Bialystok, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Laszlo Prokai
Int. J. Mol. Sci. 2021, 22(19), 10378; https://doi.org/10.3390/ijms221910378
Received: 24 August 2021 / Revised: 22 September 2021 / Accepted: 24 September 2021 / Published: 26 September 2021
(This article belongs to the Special Issue Molecular Biomarkers of Selected Diseases of Civilization 2.0)
Despite the considerable advances in diagnostic methods in medicine, central nervous system (CNS) tumors, particularly the most common ones—gliomas—remain incurable, with similar incidence rates and mortality. A growing body of literature has revealed that degradation of the extracellular matrix by matrix metalloproteinases (MMPs) might be involved in the pathogenesis of CNS tumors. However, the subfamily of MMPs, known as disintegrin and metalloproteinase (ADAM) proteins are unique due to both adhesive and proteolytic activities. The objective of our review is to present the role of ADAMs in CNS tumors, particularly their involvement in the development of malignant gliomas. Moreover, we focus on the diagnostic and prognostic significance of selected ADAMs in patients with these neoplasms. It has been proven that ADAM12, ADAMTS4 and 5 are implicated in the proliferation and invasion of glioma cells. In addition, ADAM8 and ADAM19 are correlated with the invasive activity of glioma cells and unfavorable survival, while ADAM9, -10 and -17 are associated with tumor grade and histological type of gliomas and can be used as prognostic factors. In conclusion, several ADAMs might serve as potential diagnostic and prognostic biomarkers as well as therapeutic targets for malignant CNS tumors. However, future research on ADAMs biology should be performed to elucidate new strategies for tumor diagnosis and treatment of patients with these malignancies. View Full-Text
Keywords: ADAM; ADAMTS; biomarker; central nervous system; tumor ADAM; ADAMTS; biomarker; central nervous system; tumor
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MDPI and ACS Style

Łukaszewicz-Zając, M.; Dulewicz, M.; Mroczko, B. A Disintegrin and Metalloproteinase (ADAM) Family: Their Significance in Malignant Tumors of the Central Nervous System (CNS). Int. J. Mol. Sci. 2021, 22, 10378. https://doi.org/10.3390/ijms221910378

AMA Style

Łukaszewicz-Zając M, Dulewicz M, Mroczko B. A Disintegrin and Metalloproteinase (ADAM) Family: Their Significance in Malignant Tumors of the Central Nervous System (CNS). International Journal of Molecular Sciences. 2021; 22(19):10378. https://doi.org/10.3390/ijms221910378

Chicago/Turabian Style

Łukaszewicz-Zając, Marta, Maciej Dulewicz, and Barbara Mroczko. 2021. "A Disintegrin and Metalloproteinase (ADAM) Family: Their Significance in Malignant Tumors of the Central Nervous System (CNS)" International Journal of Molecular Sciences 22, no. 19: 10378. https://doi.org/10.3390/ijms221910378

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