Potential Antioxidant and Anti-Inflammatory Function of Gynura procumbens Polyphenols Ligand

Kim, Hun Hwan; Ha, Sang Eun; Vetrivel, Preethi; Bhosale, Pritam Bhagwan; Kim, Seong Min; Kim, Gon Sup

doi:10.3390/ijms22168716

Open AccessArticle

Potential Antioxidant and Anti-Inflammatory Function of Gynura procumbens Polyphenols Ligand

by

Hun Hwan Kim

,

Sang Eun Ha

,

Preethi Vetrivel

,

Pritam Bhagwan Bhosale

,

Seong Min Kim

and

Gon Sup Kim

^*

Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, Korea

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2021, 22(16), 8716; https://doi.org/10.3390/ijms22168716

Submission received: 15 July 2021 / Revised: 10 August 2021 / Accepted: 12 August 2021 / Published: 13 August 2021

(This article belongs to the Special Issue Antioxidant and Cellular Defense Properties of Phytochemicals)

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Abstract

The antioxidant and anti-inflammatory potentials of polyphenols contained in Gynura procumbens (GP) extract were systematically analyzed. Polyphenols in GP were analyzed for nine peaks using high-performance liquid chromatography (HPLC) combined with mass spectrometry (MS), and quantitatively determined through each standard. A total of nine polyphenolic compounds were identified in the samples and their MS data were tabulated. To determine the potential of bioactive ingredients targeting DPPH and COX-2, we analyzed them by ultrafiltration combined with LC. The results identified the major compounds exhibiting binding affinity for DPPH and COX-2. Caffeic acid, kynurenic acid, and chlorogenic acid showed excellent binding affinity to DPPH and COX-2, suggesting that they can be considered as major active compounds. Additionally, the anti-inflammatory effect of GP was confirmed in vitro. This study will not only be used to provide basic data for the application of GP to the food and pharmaceutical industries, but will also provide information on effective screening methods for other medicinal plants.

Keywords: UF-LC/MS; Gynura procumbens; polyphenols; phytochemicals; antioxidant; anti-inflammatory

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MDPI and ACS Style

Kim, H.H.; Ha, S.E.; Vetrivel, P.; Bhosale, P.B.; Kim, S.M.; Kim, G.S. Potential Antioxidant and Anti-Inflammatory Function of Gynura procumbens Polyphenols Ligand. Int. J. Mol. Sci. 2021, 22, 8716. https://doi.org/10.3390/ijms22168716

AMA Style

Kim HH, Ha SE, Vetrivel P, Bhosale PB, Kim SM, Kim GS. Potential Antioxidant and Anti-Inflammatory Function of Gynura procumbens Polyphenols Ligand. International Journal of Molecular Sciences. 2021; 22(16):8716. https://doi.org/10.3390/ijms22168716

Chicago/Turabian Style

Kim, Hun Hwan, Sang Eun Ha, Preethi Vetrivel, Pritam Bhagwan Bhosale, Seong Min Kim, and Gon Sup Kim. 2021. "Potential Antioxidant and Anti-Inflammatory Function of Gynura procumbens Polyphenols Ligand" International Journal of Molecular Sciences 22, no. 16: 8716. https://doi.org/10.3390/ijms22168716

APA Style

Kim, H. H., Ha, S. E., Vetrivel, P., Bhosale, P. B., Kim, S. M., & Kim, G. S. (2021). Potential Antioxidant and Anti-Inflammatory Function of Gynura procumbens Polyphenols Ligand. International Journal of Molecular Sciences, 22(16), 8716. https://doi.org/10.3390/ijms22168716

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Potential Antioxidant and Anti-Inflammatory Function of Gynura procumbens Polyphenols Ligand

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