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Review

Inflammation, Extracellular Matrix Remodeling, and Proteostasis in Tumor Microenvironment

1
Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43125 Parma, Italy
2
Department of Medicine and Surgery, University of Insubria, Via J.H. Dunant 5, 21100 Varese, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Silvia Deaglio
Int. J. Mol. Sci. 2021, 22(15), 8102; https://doi.org/10.3390/ijms22158102
Received: 7 June 2021 / Revised: 11 July 2021 / Accepted: 26 July 2021 / Published: 28 July 2021
(This article belongs to the Special Issue Extracellular Matrix in the Tumor Microenvironment)
Cancer is a multifaceted and complex pathology characterized by uncontrolled cell proliferation and decreased apoptosis. Most cancers are recognized by an inflammatory environment rich in a myriad of factors produced by immune infiltrate cells that induce host cells to differentiate and to produce a matrix that is more favorable to tumor cells’ survival and metastasis. As a result, the extracellular matrix (ECM) is changed in terms of macromolecules content, degrading enzymes, and proteins. Altered ECM components, derived from remodeling processes, interact with a variety of surface receptors triggering intracellular signaling that, in turn, cancer cells exploit to their own benefit. This review aims to present the role of different aspects of ECM components in the tumor microenvironment. Particularly, we highlight the effect of pro- and inflammatory factors on ECM degrading enzymes, such as metalloproteases, and in a more detailed manner on hyaluronan metabolism and the signaling pathways triggered by the binding of hyaluronan with its receptors. In addition, we sought to explore the role of extracellular chaperones, especially of clusterin which is one of the most prominent in the extracellular space, in proteostasis and signaling transduction in the tumor microenvironment. Although the described tumor microenvironment components have different biological roles, they may engage common signaling pathways that favor tumor growth and metastasis. View Full-Text
Keywords: extracellular matrix remodeling; inflammation; tumor microenvironment; matrix metalloproteases; hyaluronan; extracellular chaperones; clusterin extracellular matrix remodeling; inflammation; tumor microenvironment; matrix metalloproteases; hyaluronan; extracellular chaperones; clusterin
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MDPI and ACS Style

Marozzi, M.; Parnigoni, A.; Negri, A.; Viola, M.; Vigetti, D.; Passi, A.; Karousou, E.; Rizzi, F. Inflammation, Extracellular Matrix Remodeling, and Proteostasis in Tumor Microenvironment. Int. J. Mol. Sci. 2021, 22, 8102. https://doi.org/10.3390/ijms22158102

AMA Style

Marozzi M, Parnigoni A, Negri A, Viola M, Vigetti D, Passi A, Karousou E, Rizzi F. Inflammation, Extracellular Matrix Remodeling, and Proteostasis in Tumor Microenvironment. International Journal of Molecular Sciences. 2021; 22(15):8102. https://doi.org/10.3390/ijms22158102

Chicago/Turabian Style

Marozzi, Marina, Arianna Parnigoni, Aide Negri, Manuela Viola, Davide Vigetti, Alberto Passi, Evgenia Karousou, and Federica Rizzi. 2021. "Inflammation, Extracellular Matrix Remodeling, and Proteostasis in Tumor Microenvironment" International Journal of Molecular Sciences 22, no. 15: 8102. https://doi.org/10.3390/ijms22158102

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