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Review

Genetic and Molecular Aspects of Drug-Induced QT Interval Prolongation

1
School of Medicine and Health Sciences, Universidad del Rosario, Bogotá 111221, Colombia
2
GENIUROS Research Group, Center for Research in Genetics and Genomics (CIGGUR), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá 111221, Colombia
3
Institute for Immunological Research, University of Cartagena, Cartagena 130014, Colombia
*
Author to whom correspondence should be addressed.
Academic Editor: Narcis Tribulova
Int. J. Mol. Sci. 2021, 22(15), 8090; https://doi.org/10.3390/ijms22158090
Received: 22 April 2021 / Revised: 4 July 2021 / Accepted: 6 July 2021 / Published: 28 July 2021
Long QT syndromes can be either acquired or congenital. Drugs are one of the many etiologies that may induce acquired long QT syndrome. In fact, many drugs frequently used in the clinical setting are a known risk factor for a prolonged QT interval, thus increasing the chances of developing torsade de pointes. The molecular mechanisms involved in the prolongation of the QT interval are common to most medications. However, there is considerable inter-individual variability in drug response, thus making the application of personalized medicine a relevant aspect in long QT syndrome, in order to evaluate the risk of every individual from a pharmacogenetic standpoint. View Full-Text
Keywords: pharmacogenetics; pharmacovigilance; drug interactions; arrhythmias; torsades de pointes; long QT syndrome pharmacogenetics; pharmacovigilance; drug interactions; arrhythmias; torsades de pointes; long QT syndrome
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MDPI and ACS Style

Baracaldo-Santamaría, D.; Llinás-Caballero, K.; Corso-Ramirez, J.M.; Restrepo, C.M.; Dominguez-Dominguez, C.A.; Fonseca-Mendoza, D.J.; Calderon-Ospina, C.A. Genetic and Molecular Aspects of Drug-Induced QT Interval Prolongation. Int. J. Mol. Sci. 2021, 22, 8090. https://doi.org/10.3390/ijms22158090

AMA Style

Baracaldo-Santamaría D, Llinás-Caballero K, Corso-Ramirez JM, Restrepo CM, Dominguez-Dominguez CA, Fonseca-Mendoza DJ, Calderon-Ospina CA. Genetic and Molecular Aspects of Drug-Induced QT Interval Prolongation. International Journal of Molecular Sciences. 2021; 22(15):8090. https://doi.org/10.3390/ijms22158090

Chicago/Turabian Style

Baracaldo-Santamaría, Daniela, Kevin Llinás-Caballero, Julián Miguel Corso-Ramirez, Carlos Martín Restrepo, Camilo Alberto Dominguez-Dominguez, Dora Janeth Fonseca-Mendoza, and Carlos Alberto Calderon-Ospina. 2021. "Genetic and Molecular Aspects of Drug-Induced QT Interval Prolongation" International Journal of Molecular Sciences 22, no. 15: 8090. https://doi.org/10.3390/ijms22158090

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