Next Article in Journal
Sympatholytic Mechanisms for the Beneficial Cardiovascular Effects of SGLT2 Inhibitors: A Research Hypothesis for Dapagliflozin’s Effects in the Adrenal Gland
Next Article in Special Issue
Genetic and Molecular Aspects of Drug-Induced QT Interval Prolongation
Previous Article in Journal
Short Chain Fatty Acid Acetate Increases TNFα-Induced MCP-1 Production in Monocytic Cells via ACSL1/MAPK/NF-κB Axis
Previous Article in Special Issue
The Diverse Roles of TNNI3K in Cardiac Disease and Potential for Treatment
Review

Understanding PITX2-Dependent Atrial Fibrillation Mechanisms through Computational Models

1
College of Information Science and Technology, Jinan University, Guangzhou 510632, China
2
Auckland Bioengineering Institute, University of Auckland, Auckland 1010, New Zealand
3
Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin 150000, China
4
Biological Physics Group, School of Physics & Astronomy, The University of Manchester, Manchester M13 9PL, UK
5
Department of Experimental Biology, University of Jaen, 23071 Jaen, Spain
*
Authors to whom correspondence should be addressed.
J.B. and Y.L. contributed equally to this work.
Academic Editors: Narcis Tribulova, Peter Hlivak and Robert Hatala
Int. J. Mol. Sci. 2021, 22(14), 7681; https://doi.org/10.3390/ijms22147681
Received: 24 June 2021 / Revised: 14 July 2021 / Accepted: 16 July 2021 / Published: 19 July 2021
Atrial fibrillation (AF) is a common arrhythmia. Better prevention and treatment of AF are needed to reduce AF-associated morbidity and mortality. Several major mechanisms cause AF in patients, including genetic predispositions to AF development. Genome-wide association studies have identified a number of genetic variants in association with AF populations, with the strongest hits clustering on chromosome 4q25, close to the gene for the homeobox transcription PITX2. Because of the inherent complexity of the human heart, experimental and basic research is insufficient for understanding the functional impacts of PITX2 variants on AF. Linking PITX2 properties to ion channels, cells, tissues, atriums and the whole heart, computational models provide a supplementary tool for achieving a quantitative understanding of the functional role of PITX2 in remodelling atrial structure and function to predispose to AF. It is hoped that computational approaches incorporating all we know about PITX2-related structural and electrical remodelling would provide better understanding into its proarrhythmic effects leading to development of improved anti-AF therapies. In the present review, we discuss advances in atrial modelling and focus on the mechanistic links between PITX2 and AF. Challenges in applying models for improving patient health are described, as well as a summary of future perspectives. View Full-Text
Keywords: cardiac arrhythmias; atrial fibrillation; PITX2; computational model; electrical remodelling; structural remodelling; calcium handling; mRNA; electrophysiology cardiac arrhythmias; atrial fibrillation; PITX2; computational model; electrical remodelling; structural remodelling; calcium handling; mRNA; electrophysiology
Show Figures

Figure 1

MDPI and ACS Style

Bai, J.; Lu, Y.; Zhu, Y.; Wang, H.; Yin, D.; Zhang, H.; Franco, D.; Zhao, J. Understanding PITX2-Dependent Atrial Fibrillation Mechanisms through Computational Models. Int. J. Mol. Sci. 2021, 22, 7681. https://doi.org/10.3390/ijms22147681

AMA Style

Bai J, Lu Y, Zhu Y, Wang H, Yin D, Zhang H, Franco D, Zhao J. Understanding PITX2-Dependent Atrial Fibrillation Mechanisms through Computational Models. International Journal of Molecular Sciences. 2021; 22(14):7681. https://doi.org/10.3390/ijms22147681

Chicago/Turabian Style

Bai, Jieyun, Yaosheng Lu, Yijie Zhu, Huijin Wang, Dechun Yin, Henggui Zhang, Diego Franco, and Jichao Zhao. 2021. "Understanding PITX2-Dependent Atrial Fibrillation Mechanisms through Computational Models" International Journal of Molecular Sciences 22, no. 14: 7681. https://doi.org/10.3390/ijms22147681

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop