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Article

Interaction between Angiotensinase Activities in Pituitary and Adrenal Glands of Wistar–Kyoto and Spontaneously Hypertensive Rats under Hypotensive or Hypertensive Treatments

1
Department of Health Sciences, University of Jaén, 23071 Jaén, Spain
2
Department of Physiology, Faculty of Health Sciences, Ceuta, University of Granada, 18071 Granada, Spain
3
Cardiovascular & Metabolic Syndrome Adviser, Rue es Planches 5, 2842 Rossemaison, Switzerland
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Joaquín García-Estañ, Felix Vargas and Rosemary Wangensteen
Int. J. Mol. Sci. 2021, 22(15), 7823; https://doi.org/10.3390/ijms22157823
Received: 25 June 2021 / Revised: 15 July 2021 / Accepted: 21 July 2021 / Published: 22 July 2021
(This article belongs to the Special Issue Molecular Interactions of Arterial Hypertension in Its Target Organs)
In the present study, we analyzed the activity of several aminopeptidases (angiotensinases) involved in the metabolism of various angiotensin peptides, in pituitary and adrenal glands of untreated Wistar–Kyoto (WKY) and spontaneously hypertensive rats (SHR) or treated with the antihypertensive drugs captopril and propranolol or with the L-Arginine hypertensive analogue L-NG-Nitroarginine Methyl Ester (L-NAME). Intra- and inter-gland correlations between angiotensinase activities were also calculated. Membrane-bound alanyl-, cystinyl-, and glutamyl-aminopeptidase activities were determined fluorometrically using aminoacyl-β-naphthylamide as substrates. Depending on the type of angiotensinase analyzed, the results reflect a complex picture showing substantial differences between glands, strains, and treatments. Alanyl-aminopeptidase responsible for the metabolism of Ang III to Ang IV appears to be the most active angiotensinase in both pituitary and adrenals of WKY and particularly in SHR. Independently of treatment, most positive correlations are observed in the pituitary gland of WKY whereas such positive correlations are predominant in adrenals of SHR. Negative inter-gland correlations were observed in control SHR and L-NAME treated WKY. Positive inter-gland correlations were observed in captopril-treated SHR and propranolol-treated WKY. These results may reflect additional mechanisms for increasing or decreasing systolic blood pressure in WKY or SHR. View Full-Text
Keywords: aminopeptidases; Wistar–Kyoto; spontaneously hypertensive rats; pituitary; adrenals; captopril; propranolol; L-NAME aminopeptidases; Wistar–Kyoto; spontaneously hypertensive rats; pituitary; adrenals; captopril; propranolol; L-NAME
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MDPI and ACS Style

Segarra, A.B.; Prieto, I.; Banegas, I.; Martínez-Cañamero, M.; Villarejo, A.B.; Domínguez-Vías, G.; de Gasparo, M.; Ramírez-Sánchez, M. Interaction between Angiotensinase Activities in Pituitary and Adrenal Glands of Wistar–Kyoto and Spontaneously Hypertensive Rats under Hypotensive or Hypertensive Treatments. Int. J. Mol. Sci. 2021, 22, 7823. https://doi.org/10.3390/ijms22157823

AMA Style

Segarra AB, Prieto I, Banegas I, Martínez-Cañamero M, Villarejo AB, Domínguez-Vías G, de Gasparo M, Ramírez-Sánchez M. Interaction between Angiotensinase Activities in Pituitary and Adrenal Glands of Wistar–Kyoto and Spontaneously Hypertensive Rats under Hypotensive or Hypertensive Treatments. International Journal of Molecular Sciences. 2021; 22(15):7823. https://doi.org/10.3390/ijms22157823

Chicago/Turabian Style

Segarra, Ana B., Isabel Prieto, Inmaculada Banegas, Magdalena Martínez-Cañamero, Ana B. Villarejo, Germán Domínguez-Vías, Marc de Gasparo, and Manuel Ramírez-Sánchez. 2021. "Interaction between Angiotensinase Activities in Pituitary and Adrenal Glands of Wistar–Kyoto and Spontaneously Hypertensive Rats under Hypotensive or Hypertensive Treatments" International Journal of Molecular Sciences 22, no. 15: 7823. https://doi.org/10.3390/ijms22157823

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