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Editorial

Special Issue: A, B and Z: The Structure, Function and Genetics of Z-DNA and Z-RNA

1
InsideOutBio, Discovery, 42 2 8th Street, Unit 3412, Charlestown, MA 02129, USA
2
External Communications Unit, Faculty of Computer Science, National Research University Higher School of Economics, 11 Pokrovsky Boulvar, 101000 Moscow, Russia
3
Laboratory of Bioinformatics, Faculty of Computer Science, National Research University Higher School of Economics, 11 Pokrovsky Boulvar, 101000 Moscow, Russia
4
Division of Pharmacology and Toxicology, Dell Pediatric Research Institute, College of Pharmacy, The University of Texas at Austin, 1400 Barbara Jordan Blvd, Austin, TX 78723, USA
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Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
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RNA BioScience Initiative, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(14), 7686; https://doi.org/10.3390/ijms22147686
Received: 7 July 2021 / Revised: 12 July 2021 / Accepted: 15 July 2021 / Published: 19 July 2021
(This article belongs to the Special Issue Z-DNA and Z-RNA: From Physical Structure to Biological Function)
It is now difficult to believe that a biological function for the left-handed Z-DNA and Z-RNA conformations was once controversial. The papers in this Special Issue, “Z-DNA and Z-RNA: from Physical Structure to Biological Function”, are based on presentations at the ABZ2021 meeting that was held virtually on 19 May 2021 and provide evidence for several biological functions of these structures. The first of its kind, this international conference gathered over 200 scientists from many disciplines to specifically address progress in research involving Z-DNA and Z-RNA. These high-energy left-handed conformers of B-DNA and A-RNA are associated with biological functions and disease outcomes, as evidenced from both mouse and human genetic studies. These alternative structures, referred to as “flipons”, form under physiological conditions, regulate type I interferon responses and induce necroptosis during viral infection. They can also stimulate genetic instability, resulting in adaptive evolution and diseases such as cancer. The meeting featured cutting-edge science that was, for the most part, unpublished. We plan for the ABZ meeting to reconvene in 2022. View Full-Text
MDPI and ACS Style

Herbert, A.; Karapetyan, S.; Poptsova, M.; Vasquez, K.M.; Vicens, Q.; Vögeli, B. Special Issue: A, B and Z: The Structure, Function and Genetics of Z-DNA and Z-RNA. Int. J. Mol. Sci. 2021, 22, 7686. https://doi.org/10.3390/ijms22147686

AMA Style

Herbert A, Karapetyan S, Poptsova M, Vasquez KM, Vicens Q, Vögeli B. Special Issue: A, B and Z: The Structure, Function and Genetics of Z-DNA and Z-RNA. International Journal of Molecular Sciences. 2021; 22(14):7686. https://doi.org/10.3390/ijms22147686

Chicago/Turabian Style

Herbert, Alan, Sergey Karapetyan, Maria Poptsova, Karen M. Vasquez, Quentin Vicens, and Beat Vögeli. 2021. "Special Issue: A, B and Z: The Structure, Function and Genetics of Z-DNA and Z-RNA" International Journal of Molecular Sciences 22, no. 14: 7686. https://doi.org/10.3390/ijms22147686

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