Next Article in Journal
Adsorption and Release of Sulfamethizole from Mesoporous Silica Nanoparticles Functionalised with Triethylenetetramine
Next Article in Special Issue
Targeting Mammalian 5-Lipoxygenase by Dietary Phenolics as an Anti-Inflammatory Mechanism: A Systematic Review
Previous Article in Journal
FOXE1-Dependent Regulation of Macrophage Chemotaxis by Thyroid Cells In Vitro and In Vivo
Previous Article in Special Issue
Influence of the Anthocyanin and Cofactor Structure on the Formation Efficiency of Naturally Derived Pyranoanthocyanins
Article

Glycyrrhizin Attenuates Portal Hypertension and Collateral Shunting via Inhibition of Extrahepatic Angiogenesis in Cirrhotic Rats

by 1,2,3,†, 1,2,3,4,†, 1,2,4, 1,2,4, 3, 1,2,3,*, 1,2,3, 1,2,3 and 1,2,3
1
Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei 11217, Taiwan
2
Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei 11217, Taiwan
3
Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan
4
Division of General Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan
*
Author to whom correspondence should be addressed.
Chon Kit Pun and Hui-Chun Huang contributed equally to this study.
Academic Editor: Maurizio Battino
Int. J. Mol. Sci. 2021, 22(14), 7662; https://doi.org/10.3390/ijms22147662
Received: 15 April 2021 / Revised: 13 July 2021 / Accepted: 15 July 2021 / Published: 17 July 2021
(This article belongs to the Collection Feature Papers in Bioactives and Nutraceuticals)
Portal hypertension develops along with liver cirrhosis then induces the formation of portal-systemic collaterals and lethal complications. Extrahepatic angiogenesis plays an important role. Glycyrrhizin has been found to exhibit anti-angiogenic features, which leads to its extensive use. However, the relevant effects of glycyrrhizin on liver cirrhosis and portal hypertension have not been evaluated. This study thus aimed to investigate the impact of glycyrrhizin on portal hypertension-related derangements in cirrhotic rats. Male Sprague-Dawley rats received bile duct ligation (BDL) to induce cirrhosis or sham operation as control. The rats were subdivided to receive glycyrrhizin (150 mg/kg/day, oral gavage) or vehicle beginning on the 15th day post operation, when BDL-induced liver fibrosis developed. The effects of glycyrrhizin were determined on the 28th day, the typical timing of BDL-induced cirrhosis. Glycyrrhizin significantly reduced portal pressure (p = 0.004). The splanchnic inflow as measured by superior mesenteric arterial flow decreased by 22% (p = 0.029). The portal-systemic collateral shunting degree reduced by 30% (p = 0.024). The mesenteric angiogenesis and phospho-VEGFR2 protein expression were also downregulated (p = 0.038 and 0.031, respectively). Glycyrrhizin did not significantly influence the liver biochemistry data. Although glycyrrhizin tended to reverse liver fibrosis, statistical significance was not reached (p = 0.069). Consistently, hepatic inflow from portal side, hepatic vascular resistance, and liver fibrosis-related protein expressions were not affected. Glycyrrhizin treatment at the stage of hepatic fibrosis still effectively attenuated portal hypertension and portosystemic collateral shunting. These beneficial effects were attributed to, at least in part, the suppression of mesenteric angiogenesis by VEGF signaling pathway downregulation. View Full-Text
Keywords: liver cirrhosis; portal hypertension; angiogenesis; portosystemic collateral shunting; glycyrrhizin liver cirrhosis; portal hypertension; angiogenesis; portosystemic collateral shunting; glycyrrhizin
Show Figures

Figure 1

MDPI and ACS Style

Pun, C.K.; Huang, H.-C.; Chang, C.-C.; Chuang, C.-L.; Yen, C.-H.; Hsu, S.-J.; Lee, F.-Y.; Hou, M.-C.; Huang, Y.-H. Glycyrrhizin Attenuates Portal Hypertension and Collateral Shunting via Inhibition of Extrahepatic Angiogenesis in Cirrhotic Rats. Int. J. Mol. Sci. 2021, 22, 7662. https://doi.org/10.3390/ijms22147662

AMA Style

Pun CK, Huang H-C, Chang C-C, Chuang C-L, Yen C-H, Hsu S-J, Lee F-Y, Hou M-C, Huang Y-H. Glycyrrhizin Attenuates Portal Hypertension and Collateral Shunting via Inhibition of Extrahepatic Angiogenesis in Cirrhotic Rats. International Journal of Molecular Sciences. 2021; 22(14):7662. https://doi.org/10.3390/ijms22147662

Chicago/Turabian Style

Pun, Chon K., Hui-Chun Huang, Ching-Chih Chang, Chiao-Lin Chuang, Chun-Hsien Yen, Shao-Jung Hsu, Fa-Yauh Lee, Ming-Chih Hou, and Yi-Hsiang Huang. 2021. "Glycyrrhizin Attenuates Portal Hypertension and Collateral Shunting via Inhibition of Extrahepatic Angiogenesis in Cirrhotic Rats" International Journal of Molecular Sciences 22, no. 14: 7662. https://doi.org/10.3390/ijms22147662

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop