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Volume 22
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Review

Neuroinflammation: A Signature or a Cause of Epilepsy?

by
Enrico Pracucci
1,
Vinoshene Pillai
1,
Didi Lamers
1,
Riccardo Parra
1 and
Silvia Landi
1,2,*
1
National Enterprise for Nanoscience and Nanotechnology (NEST), Istituto Nanoscienze Consiglio Nazionale delle Ricerche (CNR) and Scuola Normale Superiore Pisa, 56127 Pisa, Italy
2
Institute of Neuroscience CNR, 56127 Pisa, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(13), 6981; https://doi.org/10.3390/ijms22136981
Submission received: 12 April 2021 / Revised: 11 June 2021 / Accepted: 23 June 2021 / Published: 29 June 2021
(This article belongs to the Special Issue Molecular and Cellular Mechanisms in Inflammatory Synaptopathy)
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Abstract

Epilepsy can be both a primary pathology and a secondary effect of many neurological conditions. Many papers show that neuroinflammation is a product of epilepsy, and that in pathological conditions characterized by neuroinflammation, there is a higher probability to develop epilepsy. However, the bidirectional mechanism of the reciprocal interaction between epilepsy and neuroinflammation remains to be fully understood. Here, we attempt to explore and discuss the relationship between epilepsy and inflammation in some paradigmatic neurological and systemic disorders associated with epilepsy. In particular, we have chosen one representative form of epilepsy for each one of its actual known etiologies. A better understanding of the mechanistic link between neuroinflammation and epilepsy would be important to improve subject-based therapies, both for prophylaxis and for the treatment of epilepsy.
Keywords: epilepsy; neuroinflammation; brain excitability epilepsy; neuroinflammation; brain excitability

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MDPI and ACS Style

Pracucci, E.; Pillai, V.; Lamers, D.; Parra, R.; Landi, S. Neuroinflammation: A Signature or a Cause of Epilepsy? Int. J. Mol. Sci. 2021, 22, 6981. https://doi.org/10.3390/ijms22136981

AMA Style

Pracucci E, Pillai V, Lamers D, Parra R, Landi S. Neuroinflammation: A Signature or a Cause of Epilepsy? International Journal of Molecular Sciences. 2021; 22(13):6981. https://doi.org/10.3390/ijms22136981

Chicago/Turabian Style

Pracucci, Enrico, Vinoshene Pillai, Didi Lamers, Riccardo Parra, and Silvia Landi. 2021. "Neuroinflammation: A Signature or a Cause of Epilepsy?" International Journal of Molecular Sciences 22, no. 13: 6981. https://doi.org/10.3390/ijms22136981

APA Style

Pracucci, E., Pillai, V., Lamers, D., Parra, R., & Landi, S. (2021). Neuroinflammation: A Signature or a Cause of Epilepsy? International Journal of Molecular Sciences, 22(13), 6981. https://doi.org/10.3390/ijms22136981

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