Next Article in Journal
Dynamic “Molecular Portraits” of Biomembranes Drawn by Their Lateral Nanoscale Inhomogeneities
Next Article in Special Issue
Activity of Selected Group of Monoterpenes in Alzheimer’s Disease Symptoms in Experimental Model Studies—A Non-Systematic Review
Previous Article in Journal
Migration and Adhesion of B-Lymphocytes to Specific Microenvironments in Mantle Cell Lymphoma: Interplay between Signaling Pathways and the Epigenetic Landscape
Previous Article in Special Issue
Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer’s Disease
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 22
Issue 12
10.3390/ijms22126248
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Selective Extraction of Piceatannol from Passiflora edulis by-Products: Application of HSPs Strategy and Inhibition of Neurodegenerative Enzymes

by
Luana Cristina dos Santos
1,2,
Jose Antonio Mendiola
2,
Andrea del Pilar Sánchez-Camargo
3,
Gerardo Álvarez-Rivera
2,
Juliane Viganó
4,
Alejandro Cifuentes
2,
Elena Ibáñez
2,* and
Julian Martínez
1
1
Laboratory of High Pressure in Food Engineering (LAPEA), Department of Food Engineering and Technology, School of Food Engineering, University of Campinas, R. Monteiro Lobato 80, Campinas 13083-862, Brazil
2
Laboratory of Foodomics, Institute of Food Science Research, CIAL, CSIC, Nicolás Cabrera 9, 28049 Madrid, Spain
3
Department of Chemistry and Food Engineering, Faculty of Engineering, University of Los Andes, Carrera 1 No. 18A-12, Bogotá 111711, Colombia
4
Department of Chemical Engineering, Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, R. São Nicolau 210, Diadema 09913-030, Brazil
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(12), 6248; https://doi.org/10.3390/ijms22126248
Submission received: 16 April 2021 / Revised: 31 May 2021 / Accepted: 3 June 2021 / Published: 10 June 2021
(This article belongs to the Special Issue Advances on the Neuroprotective Effect of Food and Natural Bioactive Compounds on Alzheimer 2.0)
Browse Figures
Versions Notes

Abstract

Passiflora edulis by-products (PFBP) are a rich source of polyphenols, of which piceatannol has gained special attention recently. However, there are few studies involving environmentally safe methods for obtaining extracts rich in piceatannol. This work aimed to concentrate piceatannol from defatted PFBP (d-PFBP) by means of pressurized liquid extraction (PLE) and conventional extraction, using the bio-based solvents selected with the Hansen solubility parameters approach. The relative energy distance (Ra) between solvent and solute was: Benzyl Alcohol (BnOH) < Ethyl Acetate (EtOAc) < Ethanol (EtOH) < EtOH:H2O. Nonetheless, EtOH presented the best selectivity for piceatannol. Multi-cycle PLE at 110 °C was able to concentrate piceatannol 2.4 times more than conventional extraction. PLE exhibited a dependence on kinetic parameters and temperature, which could be associated with hydrogen bonding forces and the dielectric constant of the solvents. The acetylcholinesterase (AChE) and lipoxygenase (LOX) IC50 were 29.420 μg/mL and 27.682 μg/mL, respectively. The results reinforce the demand for processes to concentrate natural extracts from food by-products.
Keywords: pressurized liquid extraction; Hansen solubility parameters; passion fruit by-products; piceatannol; acetylcholinesterase pressurized liquid extraction; Hansen solubility parameters; passion fruit by-products; piceatannol; acetylcholinesterase

Share and Cite

MDPI and ACS Style

dos Santos, L.C.; Mendiola, J.A.; Sánchez-Camargo, A.d.P.; Álvarez-Rivera, G.; Viganó, J.; Cifuentes, A.; Ibáñez, E.; Martínez, J. Selective Extraction of Piceatannol from Passiflora edulis by-Products: Application of HSPs Strategy and Inhibition of Neurodegenerative Enzymes. Int. J. Mol. Sci. 2021, 22, 6248. https://doi.org/10.3390/ijms22126248

AMA Style

dos Santos LC, Mendiola JA, Sánchez-Camargo AdP, Álvarez-Rivera G, Viganó J, Cifuentes A, Ibáñez E, Martínez J. Selective Extraction of Piceatannol from Passiflora edulis by-Products: Application of HSPs Strategy and Inhibition of Neurodegenerative Enzymes. International Journal of Molecular Sciences. 2021; 22(12):6248. https://doi.org/10.3390/ijms22126248

Chicago/Turabian Style

dos Santos, Luana Cristina, Jose Antonio Mendiola, Andrea del Pilar Sánchez-Camargo, Gerardo Álvarez-Rivera, Juliane Viganó, Alejandro Cifuentes, Elena Ibáñez, and Julian Martínez. 2021. "Selective Extraction of Piceatannol from Passiflora edulis by-Products: Application of HSPs Strategy and Inhibition of Neurodegenerative Enzymes" International Journal of Molecular Sciences 22, no. 12: 6248. https://doi.org/10.3390/ijms22126248

APA Style

dos Santos, L. C., Mendiola, J. A., Sánchez-Camargo, A. d. P., Álvarez-Rivera, G., Viganó, J., Cifuentes, A., Ibáñez, E., & Martínez, J. (2021). Selective Extraction of Piceatannol from Passiflora edulis by-Products: Application of HSPs Strategy and Inhibition of Neurodegenerative Enzymes. International Journal of Molecular Sciences, 22(12), 6248. https://doi.org/10.3390/ijms22126248

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop