MYC-Induced Replicative Stress: A Double-Edged Sword for Cancer Development and Treatment
Abstract
:1. MYC Is a Transcription Factor and Oncogene
2. The Landscape of MYC-Dependent Transcription
3. Structure and Function Insights
4. Activation of Transcription by MYC
5. Transcriptional Repression by MYC
6. MYC Controls DNA Replication and Replicative Stress
7. Linking MYC-Dependent Transcription to Replicative Stress
8. Replicative Stress Is a Therapeutic Target for MYC-Driven Cancers
9. Conclusions and Perspectives
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Curti, L.; Campaner, S. MYC-Induced Replicative Stress: A Double-Edged Sword for Cancer Development and Treatment. Int. J. Mol. Sci. 2021, 22, 6168. https://doi.org/10.3390/ijms22126168
Curti L, Campaner S. MYC-Induced Replicative Stress: A Double-Edged Sword for Cancer Development and Treatment. International Journal of Molecular Sciences. 2021; 22(12):6168. https://doi.org/10.3390/ijms22126168
Chicago/Turabian StyleCurti, Laura, and Stefano Campaner. 2021. "MYC-Induced Replicative Stress: A Double-Edged Sword for Cancer Development and Treatment" International Journal of Molecular Sciences 22, no. 12: 6168. https://doi.org/10.3390/ijms22126168