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Review

Sexual Dimorphism of Corticosteroid Signaling during Kidney Development

1
Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, CEDEX, 94276 Le Kremlin-Bicêtre, France
2
Pediatric Endocrinology Department, Hôpital Universitaire Robert Debre, France & Université de Paris, 75019 Paris, France
3
Service de Génétique Moléculaire, Pharmacogénétique et Hormonologie, Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, 94275 Le Kremlin-Bicêtre, France
*
Author to whom correspondence should be addressed.
Academic Editor: Antoine Martinez
Int. J. Mol. Sci. 2021, 22(10), 5275; https://doi.org/10.3390/ijms22105275
Received: 17 April 2021 / Revised: 7 May 2021 / Accepted: 10 May 2021 / Published: 18 May 2021
(This article belongs to the Special Issue Sexual Dimorphism in (Non Reproductive) Endocrine Diseases)
Sexual dimorphism involves differences between biological sexes that go beyond sexual characteristics. In mammals, differences between sexes have been demonstrated regarding various biological processes, including blood pressure and predisposition to develop hypertension early in adulthood, which may rely on early events during development and in the neonatal period. Recent studies suggest that corticosteroid signaling pathways (comprising glucocorticoid and mineralocorticoid signaling pathways) have distinct tissue-specific expression and regulation during this specific temporal window in a sex-dependent manner, most notably in the kidney. This review outlines the evidence for a gender differential expression and activation of renal corticosteroid signaling pathways in the mammalian fetus and neonate, from mouse to human, that may favor mineralocorticoid signaling in females and glucocorticoid signaling in males. Determining the effects of such differences may shed light on short term and long term pathophysiological consequences, markedly for males. View Full-Text
Keywords: aldosterone; cortisol; mineralocorticoid and glucocorticoid receptors; neonates; kidney; development; sexual dimorphism aldosterone; cortisol; mineralocorticoid and glucocorticoid receptors; neonates; kidney; development; sexual dimorphism
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MDPI and ACS Style

Laulhé, M.; Dumeige, L.; Vu, T.A.; Hani, I.; Pussard, E.; Lombès, M.; Viengchareun, S.; Martinerie, L. Sexual Dimorphism of Corticosteroid Signaling during Kidney Development. Int. J. Mol. Sci. 2021, 22, 5275. https://doi.org/10.3390/ijms22105275

AMA Style

Laulhé M, Dumeige L, Vu TA, Hani I, Pussard E, Lombès M, Viengchareun S, Martinerie L. Sexual Dimorphism of Corticosteroid Signaling during Kidney Development. International Journal of Molecular Sciences. 2021; 22(10):5275. https://doi.org/10.3390/ijms22105275

Chicago/Turabian Style

Laulhé, Margaux, Laurence Dumeige, Thi A. Vu, Imene Hani, Eric Pussard, Marc Lombès, Say Viengchareun, and Laetitia Martinerie. 2021. "Sexual Dimorphism of Corticosteroid Signaling during Kidney Development" International Journal of Molecular Sciences 22, no. 10: 5275. https://doi.org/10.3390/ijms22105275

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