Next Article in Journal
Caenorhabditis elegans as a Model System for Duchenne Muscular Dystrophy
Next Article in Special Issue
Sexual Dimorphism of Corticosteroid Signaling during Kidney Development
Previous Article in Journal
BiFC Method Based on Intraorganellar Protein Crowding Detects Oleate-Dependent Peroxisomal Targeting of Pichia pastoris Malate Dehydrogenase
Previous Article in Special Issue
Sexual Dimorphism in Glucocorticoid Stress Response
Review

The Sexually Dimorphic Adrenal Cortex: Implications for Adrenal Disease

Université Côte d’Azur, Inserm, CNRS, Institut de Biologie Valrose, 06108 Nice, France
*
Authors to whom correspondence should be addressed.
Academic Editor: George E. Barreto
Int. J. Mol. Sci. 2021, 22(9), 4889; https://doi.org/10.3390/ijms22094889
Received: 22 March 2021 / Revised: 26 April 2021 / Accepted: 28 April 2021 / Published: 5 May 2021
(This article belongs to the Special Issue Sexual Dimorphism in (Non Reproductive) Endocrine Diseases)
Many adrenocortical diseases are more prevalent in women than in men, but the reasons underlying this sex bias are still unknown. Recent studies involving gonadectomy and sex hormone replacement experiments in mice have shed some light onto the molecular basis of sexual dimorphism in the adrenal cortex. Indeed, it has been shown that gonadal hormones influence many aspects of adrenal physiology, ranging from stem cell-dependent tissue turnover to steroidogenesis and X-zone dynamics. This article reviews current knowledge on adrenal cortex sexual dimorphism and the potential mechanisms underlying sex hormone influence of adrenal homeostasis. Both topics are expected to contribute to personalized and novel therapeutic approaches in the future. View Full-Text
Keywords: adrenal cortex; sexual dimorphism; sex hormones; proliferation; adrenocortical carcinoma; Cushing’s syndrome; Addison’s disease; stem cells adrenal cortex; sexual dimorphism; sex hormones; proliferation; adrenocortical carcinoma; Cushing’s syndrome; Addison’s disease; stem cells
Show Figures

Figure 1

MDPI and ACS Style

Lyraki, R.; Schedl, A. The Sexually Dimorphic Adrenal Cortex: Implications for Adrenal Disease. Int. J. Mol. Sci. 2021, 22, 4889. https://doi.org/10.3390/ijms22094889

AMA Style

Lyraki R, Schedl A. The Sexually Dimorphic Adrenal Cortex: Implications for Adrenal Disease. International Journal of Molecular Sciences. 2021; 22(9):4889. https://doi.org/10.3390/ijms22094889

Chicago/Turabian Style

Lyraki, Rodanthi, and Andreas Schedl. 2021. "The Sexually Dimorphic Adrenal Cortex: Implications for Adrenal Disease" International Journal of Molecular Sciences 22, no. 9: 4889. https://doi.org/10.3390/ijms22094889

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop