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Volume 22
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10.3390/ijms22010122
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Review

Tracking the Genetic Susceptibility Background of B-Cell Non-Hodgkin’s Lymphomas from Genome-Wide Association Studies

by
Isaias Hernández-Verdin
1,2,
Karim Labreche
1,2,
Marion Benazra
1,2,3,4,5,
Karima Mokhtari
6,7,
Khê Hoang-Xuan
1,2,3,4,7,8 and
Agusti Alentorn
1,2,3,4,7,*
1
Faculté de Médecine, Sorbonne Université, 75013 Paris, France
2
Brain and Spine Institute (ICM), 75013 Paris, France
3
National Institute of Health and Medical Research (Inserm) U 1127, 75013 Paris, France
4
National Center for Scientific Research, Joint Research Unit 7225, 75013 Paris, France
5
Brain and Spine Institute (ICM), iGenSeq Platform, 75013 Paris, France
6
Raymond Escourolle Department of Neuropathology, Public Assistance–Hospitals of Paris, Hospital Group of Pitié-Salpêtrière, 75013 Paris, France
7
Assistance Publique Hôpitaux de Paris (APHP), Department of Neurology-2, Groupe Hospitalier Pitié Salpêtrière, 75013 Paris, France
8
Réseau Expert National LOC (Lymphomes Oculo-Cérébraux), Groupe Hospitalier Pitié Salpêtrière, 75013 Paris, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(1), 122; https://doi.org/10.3390/ijms22010122
Submission received: 5 November 2020 / Revised: 10 December 2020 / Accepted: 18 December 2020 / Published: 24 December 2020
(This article belongs to the Section Molecular Genetics and Genomics)
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Abstract

B-cell non-Hodgkin’s lymphoma (NHL) risk associations had been mainly attributed to family history of the disease, inflammation, and immune components including human leukocyte antigen (HLA) genetic variations. Nevertheless, a broad range of genome-wide association studies (GWAS) have shed light into the identification of several genetic variants presumptively associated with B-cell NHL etiologies, survival or shared genetic risk with other diseases. The present review aims to overview HLA structure and diversity and summarize the evidence of genetic variations, by GWAS, on five NHL subtypes (diffuse large B-cell lymphoma DLBCL, follicular lymphoma FL, chronic lymphocytic leukemia CLL, marginal zone lymphoma MZL, and primary central nervous system lymphoma PCNSL). Evidence indicates that the HLA zygosity status in B-cell NHL might promote immune escape and that genome-wide significance variants can give biological insight but also potential therapeutic markers such as WEE1 in DLBCL. However, additional studies are needed, especially for non-DLBCL, to replicate the associations found to date.
Keywords: B-cell non-Hodgkin’s lymphoma; GWAS; cancer risk; HLA B-cell non-Hodgkin’s lymphoma; GWAS; cancer risk; HLA

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MDPI and ACS Style

Hernández-Verdin, I.; Labreche, K.; Benazra, M.; Mokhtari, K.; Hoang-Xuan, K.; Alentorn, A. Tracking the Genetic Susceptibility Background of B-Cell Non-Hodgkin’s Lymphomas from Genome-Wide Association Studies. Int. J. Mol. Sci. 2021, 22, 122. https://doi.org/10.3390/ijms22010122

AMA Style

Hernández-Verdin I, Labreche K, Benazra M, Mokhtari K, Hoang-Xuan K, Alentorn A. Tracking the Genetic Susceptibility Background of B-Cell Non-Hodgkin’s Lymphomas from Genome-Wide Association Studies. International Journal of Molecular Sciences. 2021; 22(1):122. https://doi.org/10.3390/ijms22010122

Chicago/Turabian Style

Hernández-Verdin, Isaias, Karim Labreche, Marion Benazra, Karima Mokhtari, Khê Hoang-Xuan, and Agusti Alentorn. 2021. "Tracking the Genetic Susceptibility Background of B-Cell Non-Hodgkin’s Lymphomas from Genome-Wide Association Studies" International Journal of Molecular Sciences 22, no. 1: 122. https://doi.org/10.3390/ijms22010122

APA Style

Hernández-Verdin, I., Labreche, K., Benazra, M., Mokhtari, K., Hoang-Xuan, K., & Alentorn, A. (2021). Tracking the Genetic Susceptibility Background of B-Cell Non-Hodgkin’s Lymphomas from Genome-Wide Association Studies. International Journal of Molecular Sciences, 22(1), 122. https://doi.org/10.3390/ijms22010122

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