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Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis

Roles of Autophagy in Oxidative Stress

by 1,2, 2,3, 2,3, 1,2, 1,2,3,* and 2,3,*
Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea
Biomedical Science Institute, Kyung Hee University, Seoul 02447, Korea
Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Korea
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(9), 3289;
Received: 30 March 2020 / Revised: 1 May 2020 / Accepted: 4 May 2020 / Published: 6 May 2020
(This article belongs to the Special Issue Autophagy in Health, Ageing and Disease 2.0)
Autophagy is a catabolic process for unnecessary or dysfunctional cytoplasmic contents by lysosomal degradation pathways. Autophagy is implicated in various biological processes such as programmed cell death, stress responses, elimination of damaged organelles and development. The role of autophagy as a crucial mediator has been clarified and expanded in the pathological response to redox signalling. Autophagy is a major sensor of the redox signalling. Reactive oxygen species (ROS) are highly reactive molecules that are generated as by-products of cellular metabolism, principally by mitochondria. Mitochondrial ROS (mROS) are beneficial or detrimental to cells depending on their concentration and location. mROS function as redox messengers in intracellular signalling at physiologically low level, whereas excessive production of mROS causes oxidative damage to cellular constituents and thus incurs cell death. Hence, the balance of autophagy-related stress adaptation and cell death is important to comprehend redox signalling-related pathogenesis. In this review, we attempt to provide an overview the basic mechanism and function of autophagy in the context of response to oxidative stress and redox signalling in pathology. View Full-Text
Keywords: autophagy; reactive oxygen species; oxidative stress autophagy; reactive oxygen species; oxidative stress
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MDPI and ACS Style

Yun, H.R.; Jo, Y.H.; Kim, J.; Shin, Y.; Kim, S.S.; Choi, T.G. Roles of Autophagy in Oxidative Stress. Int. J. Mol. Sci. 2020, 21, 3289.

AMA Style

Yun HR, Jo YH, Kim J, Shin Y, Kim SS, Choi TG. Roles of Autophagy in Oxidative Stress. International Journal of Molecular Sciences. 2020; 21(9):3289.

Chicago/Turabian Style

Yun, Hyeong R., Yong H. Jo, Jieun Kim, Yoonhwa Shin, Sung S. Kim, and Tae G. Choi 2020. "Roles of Autophagy in Oxidative Stress" International Journal of Molecular Sciences 21, no. 9: 3289.

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