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Open AccessProject Report

Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project

1
Department Environment and Health, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
2
National Food Institute, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark
3
The Institute for Global Food Security, School of Biological Sciences, Queen’s University Belfast, Belfast BT9 5DL, Northern Ireland, UK
4
Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital, SE-14186 Stockholm, Sweden
5
Institute of Medical Sciences, School of Medicine, Medical Sciences & Nutrition, Foresterhill, Aberdeen AB23 8ZD, UK
6
Department of Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM Utrecht, The Netherlands
7
Carl von Linné Clinic, Uppsala Science Park, S-751 83 Uppsala, Sweden
8
Department of Obstetrics and Gynaecology, Institute of Clinical Medicine, University of Tartu and Competence Centre on Health Technologies, Teaduspargi 13, 50411 Tartu, Estonia
9
Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)—UMR_S 1085, F-35000 Rennes, France
10
Neuroendocrinology Unit, GIGA-Institute, University of Liège, Belgium.1, Avenue de l’hôpital, 4000 Liège, Belgium
11
Department of Immunology, Tufts University School of Medicine, Boston, MA 0211, USA
12
Department of Chemistry and Biotechnology, School of Science, Tallinn University of Technology, 12618 Tallinn, Estonia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(9), 3215; https://doi.org/10.3390/ijms21093215
Received: 31 March 2020 / Revised: 21 April 2020 / Accepted: 29 April 2020 / Published: 1 May 2020
(This article belongs to the Special Issue Advances in the Research of Endocrine Disrupting Chemicals 2.0)
Currently available test methods are not well-suited for the identification of chemicals that disturb hormonal processes involved in female reproductive development and function. This renders women’s reproductive health at increasing risk globally, which, coupled with increasing incidence rates of reproductive disorders, is of great concern. A woman’s reproductive health is largely established during embryonic and fetal development and subsequently matures during puberty. The endocrine system influences development, maturation, and function of the female reproductive system, thereby making appropriate hormone levels imperative for correct functioning of reproductive processes. It is concerning that the effects of human-made chemicals on the endocrine system and female reproductive health are poorly addressed in regulatory chemical safety assessment, partly because adequate test methods are lacking. Our EU-funded project FREIA aims to address this need by increasing understanding of how endocrine disrupting chemicals (EDCs) can impact female reproductive health. We will use this information to provide better test methods that enable fit-for-purpose chemical regulation and then share our knowledge, promote a sustainable society, and improve the reproductive health of women globally. View Full-Text
Keywords: female reproductive health; endocrine disrupting chemicals; test methods; risk assessment; fertility; ovary; oocyte; adrenal; mammary gland; steroidogenesis; bioassay female reproductive health; endocrine disrupting chemicals; test methods; risk assessment; fertility; ovary; oocyte; adrenal; mammary gland; steroidogenesis; bioassay
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MDPI and ACS Style

van Duursen, M.B.M.; Boberg, J.; Christiansen, S.; Connolly, L.; Damdimopoulou, P.; Filis, P.; Fowler, P.A.; Gadella, B.M.; Holte, J.; Jääger, K.; Johansson, H.K.L.; Li, T.; Mazaud-Guittot, S.; Parent, A.-S.; Salumets, A.; Soto, A.M.; Svingen, T.; Velthut-Meikas, A.; Bay Wedebye, E.; Xie, Y.; van den Berg, M. Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project. Int. J. Mol. Sci. 2020, 21, 3215. https://doi.org/10.3390/ijms21093215

AMA Style

van Duursen MBM, Boberg J, Christiansen S, Connolly L, Damdimopoulou P, Filis P, Fowler PA, Gadella BM, Holte J, Jääger K, Johansson HKL, Li T, Mazaud-Guittot S, Parent A-S, Salumets A, Soto AM, Svingen T, Velthut-Meikas A, Bay Wedebye E, Xie Y, van den Berg M. Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project. International Journal of Molecular Sciences. 2020; 21(9):3215. https://doi.org/10.3390/ijms21093215

Chicago/Turabian Style

van Duursen, Majorie B.M.; Boberg, Julie; Christiansen, Sofie; Connolly, Lisa; Damdimopoulou, Pauliina; Filis, Panagiotis; Fowler, Paul A.; Gadella, Bart M.; Holte, Jan; Jääger, Kersti; Johansson, Hanna K.L.; Li, Tianyi; Mazaud-Guittot, Séverine; Parent, Anne-Simone; Salumets, Andres; Soto, Ana M.; Svingen, Terje; Velthut-Meikas, Agne; Bay Wedebye, Eva; Xie, Yuling; van den Berg, Martin. 2020. "Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project" Int. J. Mol. Sci. 21, no. 9: 3215. https://doi.org/10.3390/ijms21093215

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