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ERGO: Breaking Down the Wall between Human Health and Environmental Testing of Endocrine Disrupters

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Department of Biology, University of Southern Denmark, 5230 Odense M, Denmark
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Matthiessen Consultancy, Dolfan Barn, Beulah LD5 4UE, UK
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Department of Environmental Science, Aarhus University, 4000 Roskilde, Denmark
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UFZ Department of Ecological Chemistry, Helmholtz Centre for Environmental Research, Permoserstraße 15, 04318 Leipzig, Germany
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Institute of Organic Chemistry, Technical University Bergakademie Freiberg, Leipziger Straße 29, 09596 Freiberg, Germany
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Zebrafishlab, Department of Veterinary Sciences, University of Antwerp, 2610 Wilrijk, Belgium
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AquaTT, Olympic House, Pleasants Street, D08 H67X Dublin, Ireland
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Functional Genomics of Thyroid Hormone Signaling Group, Institut de Génomique Fonctionnelle de Lyon Ecole Normale Supérieure de Lyon, 69007 Lyon, France
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UMR7221 Molecular Physiology and Adaption, Centre National de le Recherche Scientifique—Muséum National d’Histoire Naturelle, CEDEX 05, 75231 Paris, France
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Abt. Ökophysiologie und Aquakultur Leibniz-Institut für Gewässerökologie und Binnenfischerei, 12587 Berlin, Germany
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RECETOX, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
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Laboratoire Recherche Environnementale, L’ORÉAL Recherche & Innovation, 93601 Aulnay-sous-Bois, France
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German Environment Agency (UBA), Section IV2.3 Chemicals, 06844 Dessau-Roßlau, Germany
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BASF SE, Experimental Toxicology and Ecotoxicology, 67098 Ludwigshafen, Germany
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Graduate School of Nanobioscience, Yokohama City University, Yokohama 236-0027, Japan
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Centre for Organismal Studies, University of Heidelberg, 69120 Heidelberg, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(8), 2954; https://doi.org/10.3390/ijms21082954
Received: 31 March 2020 / Revised: 16 April 2020 / Accepted: 20 April 2020 / Published: 22 April 2020
(This article belongs to the Special Issue Advances in the Research of Endocrine Disrupting Chemicals 2.0)
ERGO (EndocRine Guideline Optimization) is the acronym of a European Union-funded research and innovation action, that aims to break down the wall between mammalian and non-mammalian vertebrate regulatory testing of endocrine disruptors (EDs), by identifying, developing and aligning thyroid-related biomarkers and endpoints (B/E) for the linkage of effects between vertebrate classes. To achieve this, an adverse outcome pathway (AOP) network covering various modes of thyroid hormone disruption (THD) in multiple vertebrate classes will be developed. The AOP development will be based on existing and new data from in vitro and in vivo experiments with fish, amphibians and mammals, using a battery of different THDs. This will provide the scientifically plausible and evidence-based foundation for the selection of B/E and assays in lower vertebrates, predictive of human health outcomes. These assays will be prioritized for validation at OECD (Organization for Economic Cooperation and Development) level. ERGO will re-think ED testing strategies from in silico methods to in vivo testing and develop, optimize and validate existing in vivo and early life-stage OECD guidelines, as well as new in vitro protocols for THD. This strategy will reduce requirements for animal testing by preventing duplication of testing in mammals and non-mammalian vertebrates and increase the screening capacity to enable more chemicals to be tested for ED properties. View Full-Text
Keywords: endocrine disruption; thyroid hormone disruption; AOP; adverse outcome pathway; OECD; test guideline; integrated approach to testing and assessment; IATA; cross-species extrapolation; biomarkers endocrine disruption; thyroid hormone disruption; AOP; adverse outcome pathway; OECD; test guideline; integrated approach to testing and assessment; IATA; cross-species extrapolation; biomarkers
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Figure 1

MDPI and ACS Style

Holbech, H.; Matthiessen, P.; Hansen, M.; Schüürmann, G.; Knapen, D.; Reuver, M.; Flamant, F.; Sachs, L.; Kloas, W.; Hilscherova, K.; Leonard, M.; Arning, J.; Strauss, V.; Iguchi, T.; Baumann, L. ERGO: Breaking Down the Wall between Human Health and Environmental Testing of Endocrine Disrupters. Int. J. Mol. Sci. 2020, 21, 2954. https://doi.org/10.3390/ijms21082954

AMA Style

Holbech H, Matthiessen P, Hansen M, Schüürmann G, Knapen D, Reuver M, Flamant F, Sachs L, Kloas W, Hilscherova K, Leonard M, Arning J, Strauss V, Iguchi T, Baumann L. ERGO: Breaking Down the Wall between Human Health and Environmental Testing of Endocrine Disrupters. International Journal of Molecular Sciences. 2020; 21(8):2954. https://doi.org/10.3390/ijms21082954

Chicago/Turabian Style

Holbech, Henrik; Matthiessen, Peter; Hansen, Martin; Schüürmann, Gerrit; Knapen, Dries; Reuver, Marieke; Flamant, Frédéric; Sachs, Laurent; Kloas, Werner; Hilscherova, Klara; Leonard, Marc; Arning, Jürgen; Strauss, Volker; Iguchi, Taisen; Baumann, Lisa. 2020. "ERGO: Breaking Down the Wall between Human Health and Environmental Testing of Endocrine Disrupters" Int. J. Mol. Sci. 21, no. 8: 2954. https://doi.org/10.3390/ijms21082954

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