The Role of Aryl Hydrocarbon Receptor (AhR) in Brain Tumors
Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Timakova Str. 2, 630117 Novosibirsk, Russia
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Int. J. Mol. Sci. 2020, 21(8), 2863; https://doi.org/10.3390/ijms21082863
Received: 11 March 2020
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Revised: 16 April 2020
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Accepted: 18 April 2020
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Published: 20 April 2020
(This article belongs to the Special Issue How the AHR Became Important-A Lesson in How Basic Science Leads to Actionable Translational Medicine)
Primary brain tumors, both malignant and benign, are diagnosed in adults at an incidence rate of approximately 23 people per 100 thousand. The role of AhR in carcinogenesis has been a subject of debate, given that this protein may act as either an oncogenic protein or a tumor suppressor in different cell types and contexts. Lately, there is growing evidence that aryl hydrocarbon receptor (AhR) plays an important part in the development of brain tumors. The role of AhR in brain tumors is complicated, depending on the type of tumor, on ligands that activate AhR, and other features of the pathological process. In this review, we summarize current knowledge about AhR in relation to brain tumors and provide an overview of AhR’s potential as a therapeutic target.
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MDPI and ACS Style
Perepechaeva, M.L.; Grishanova, A.Y. The Role of Aryl Hydrocarbon Receptor (AhR) in Brain Tumors. Int. J. Mol. Sci. 2020, 21, 2863. https://doi.org/10.3390/ijms21082863
AMA Style
Perepechaeva ML, Grishanova AY. The Role of Aryl Hydrocarbon Receptor (AhR) in Brain Tumors. International Journal of Molecular Sciences. 2020; 21(8):2863. https://doi.org/10.3390/ijms21082863
Chicago/Turabian StylePerepechaeva, Maria L., and Alevtina Y. Grishanova. 2020. "The Role of Aryl Hydrocarbon Receptor (AhR) in Brain Tumors" International Journal of Molecular Sciences 21, no. 8: 2863. https://doi.org/10.3390/ijms21082863
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