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Review

Nuclear Functions of the Tyrosine Kinase Src

1
Multifactorial Disease and Complex Phenotype Research Area, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
2
Department of Medico-Surgical Sciences and Biotechnology, Polo Pontino, Sapienza University, 04100 Latina, Italy
*
Author to whom correspondence should be addressed.
These authors contribute equally to this work.
Int. J. Mol. Sci. 2020, 21(8), 2675; https://doi.org/10.3390/ijms21082675
Received: 18 March 2020 / Revised: 9 April 2020 / Accepted: 10 April 2020 / Published: 11 April 2020
(This article belongs to the Special Issue Tyrosine Kinases in Health and Disease)
Src is the representative member of the Src-family kinases (SFKs), a group of tyrosine kinases involved in several cellular processes. Its main function has been for long confined to the plasma membrane/cytoplasm compartment, being a myristoylated protein anchored to the cell membrane and functioning downstream to receptors, most of them lacking intrinsic kinase activity. In the last decades, new roles for some SFKs have been described in the nuclear compartment, suggesting that these proteins can also be involved in directly regulating gene transcription or nucleoskeleton architecture. In this review, we focused on those nuclear functions specifically attributable to Src, by considering its function as both tyrosine kinase and adapting molecule. In particular, we addressed the Src involvement in physiological as well as in pathological conditions, especially in tumors. View Full-Text
Keywords: Tyrosine phosphorylation; Src-family kinases; subcellular localization; nucleus; oncogenes Tyrosine phosphorylation; Src-family kinases; subcellular localization; nucleus; oncogenes
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MDPI and ACS Style

Bagnato, G.; Leopizzi, M.; Urciuoli, E.; Peruzzi, B. Nuclear Functions of the Tyrosine Kinase Src. Int. J. Mol. Sci. 2020, 21, 2675. https://doi.org/10.3390/ijms21082675

AMA Style

Bagnato G, Leopizzi M, Urciuoli E, Peruzzi B. Nuclear Functions of the Tyrosine Kinase Src. International Journal of Molecular Sciences. 2020; 21(8):2675. https://doi.org/10.3390/ijms21082675

Chicago/Turabian Style

Bagnato, Giulia, Martina Leopizzi, Enrica Urciuoli, and Barbara Peruzzi. 2020. "Nuclear Functions of the Tyrosine Kinase Src" International Journal of Molecular Sciences 21, no. 8: 2675. https://doi.org/10.3390/ijms21082675

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