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Open AccessArticle

Enhancement of Neurite Outgrowth by Warming Biomaterial Ultrasound Treatment

1
Institute of Biomedical Engineering, National Chiao Tung University, Hsinchu City 300-41, Taiwan
2
Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli County 358-69, Taiwan
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(6), 2236; https://doi.org/10.3390/ijms21062236 (registering DOI)
Received: 31 December 2019 / Revised: 14 March 2020 / Accepted: 19 March 2020 / Published: 23 March 2020
(This article belongs to the Special Issue Bio-Engineering and Nano-Medicine)
Ultrasound is a method for enhancing neurite outgrowth because of its thermal effect. In order to reach the working temperature to enhance neurite outgrowth, long-time treatment by ultrasound is necessary, while acknowledging that the treatment poses a high risk of damaging nerve cells. To overcome this problem, we developed a method that shortens the ultrasonic treatment time with a warming biomaterial. In this study, we used Fe3O4 nanoparticle-embedded polycaprolactone (PCL) as a sonosensitized biomaterial, which has an excellent heating rate due to its high acoustic attenuation. With this material, the ultrasonic treatment time for enhancing neurite outgrowth could be effectively shortened. Ultrasonic treatment could also increase neuronal function combined with the warming biomaterial, with more promoter neuronal function than only ultrasound. Moreover, the risk of overexposure can be avoided by the use of the warming biomaterial by reducing the ultrasonic treatment time, providing better effectiveness. View Full-Text
Keywords: ultrasound; thermal effect; neurite outgrowth; sonosensitized biomaterial; acoustic attenuation ultrasound; thermal effect; neurite outgrowth; sonosensitized biomaterial; acoustic attenuation
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MDPI and ACS Style

Chen, J.-C.; Su, C.-M.; Chen, G.-S.; Lai, C.-C.; Chen, C.-Y.; Lin, K. .-C.; Lin, F.-H.; Dong, G.-C. Enhancement of Neurite Outgrowth by Warming Biomaterial Ultrasound Treatment. Int. J. Mol. Sci. 2020, 21, 2236.

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