Next Article in Journal
Proteomic Profiles and Biological Processes of Relapsed vs. Non-Relapsed Pediatric Hodgkin Lymphoma
Previous Article in Journal
Dimension Reduction and Clustering Models for Single-Cell RNA Sequencing Data: A Comparative Study
Open AccessReview

Melatonin Relations with Energy Metabolism as Possibly Involved in Fatal Mountain Road Traffic Accidents

1
Laboratory of Extreme Environments, Department of Physiology and Biophysics, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 8380453, Chile
2
Faculty of Medicine, Campus Los Leones, San Sebastián University, Providencia, Santiago 7500000, Chile
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(6), 2184; https://doi.org/10.3390/ijms21062184
Received: 26 February 2020 / Revised: 13 March 2020 / Accepted: 15 March 2020 / Published: 22 March 2020
(This article belongs to the Section Bioactives and Nutraceuticals)
Previous results evidenced acute exposure to high altitude (HA) weakening the relation between daily melatonin cycle and the respiratory quotient. This review deals with the threat extreme environments pose on body time order, particularly concerning energy metabolism. Working at HA, at poles, or in space challenge our ancestral inborn body timing system. This conflict may also mark many aspects of our current lifestyle, involving shift work, rapid time zone crossing, and even prolonged office work in closed buildings. Misalignments between external and internal rhythms, in the short term, traduce into risk of mental and physical performance shortfalls, mood changes, quarrels, drug and alcohol abuse, failure to accomplish with the mission and, finally, high rates of fatal accidents. Relations of melatonin with energy metabolism being altered under a condition of hypoxia focused our attention on interactions of the indoleamine with redox state, as well as, with autonomic regulations. Individual tolerance/susceptibility to such interactions may hint at adequately dealing with body timing disorders under extreme conditions. View Full-Text
Keywords: melatonin; dysrhythmia; mountain road death melatonin; dysrhythmia; mountain road death
Show Figures

Figure 1

MDPI and ACS Style

Behn, C.; De Gregorio, N. Melatonin Relations with Energy Metabolism as Possibly Involved in Fatal Mountain Road Traffic Accidents. Int. J. Mol. Sci. 2020, 21, 2184.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop