Next Article in Journal
Dimension Reduction and Clustering Models for Single-Cell RNA Sequencing Data: A Comparative Study
Next Article in Special Issue
“Mitotic Slippage” and Extranuclear DNA in Cancer Chemoresistance: A Focus on Telomeres
Previous Article in Journal
Fucoxanthin Ameliorates Atopic Dermatitis Symptoms by Regulating Keratinocytes and Regulatory Innate Lymphoid Cells
Previous Article in Special Issue
Cell Fusion-Mediated Tissue Regeneration as an Inducer of Polyploidy and Aneuploidy
Review

XPA: DNA Repair Protein of Significant Clinical Importance

1
Department of Genetics, Cancer Research Institute, Biomedical Research Center, Slovak Academy Sciences, 845 05 Bratislava, Slovak Republic
2
Department of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YG, UK
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(6), 2182; https://doi.org/10.3390/ijms21062182
Received: 6 February 2020 / Revised: 18 March 2020 / Accepted: 18 March 2020 / Published: 22 March 2020
The nucleotide excision repair (NER) pathway is activated in response to a broad spectrum of DNA lesions, including bulky lesions induced by platinum-based chemotherapeutic agents. Expression levels of NER factors and resistance to chemotherapy has been examined with some suggestion that NER plays a role in tumour resistance; however, there is a great degree of variability in these studies. Nevertheless, recent clinical studies have suggested Xeroderma Pigmentosum group A (XPA) protein, a key regulator of the NER pathway that is essential for the repair of DNA damage induced by platinum-based chemotherapeutics, as a potential prognostic and predictive biomarker for response to treatment. XPA functions in damage verification step in NER, as well as a molecular scaffold to assemble other NER core factors around the DNA damage site, mediated by protein–protein interactions. In this review, we focus on the interacting partners and mechanisms of regulation of the XPA protein. We summarize clinical oncology data related to this DNA repair factor, particularly its relationship with treatment outcome, and examine the potential of XPA as a target for small molecule inhibitors. View Full-Text
Keywords: XPA protein; nucleotide excision repair; biomarker; cancer; small molecule inhibitors; single nucleotide polymorphism; prognostic and predictive value XPA protein; nucleotide excision repair; biomarker; cancer; small molecule inhibitors; single nucleotide polymorphism; prognostic and predictive value
Show Figures

Figure 1

MDPI and ACS Style

Borszéková Pulzová, L.; Ward, T.A.; Chovanec, M. XPA: DNA Repair Protein of Significant Clinical Importance. Int. J. Mol. Sci. 2020, 21, 2182. https://doi.org/10.3390/ijms21062182

AMA Style

Borszéková Pulzová L, Ward TA, Chovanec M. XPA: DNA Repair Protein of Significant Clinical Importance. International Journal of Molecular Sciences. 2020; 21(6):2182. https://doi.org/10.3390/ijms21062182

Chicago/Turabian Style

Borszéková Pulzová, Lucia, Thomas A. Ward, and Miroslav Chovanec. 2020. "XPA: DNA Repair Protein of Significant Clinical Importance" International Journal of Molecular Sciences 21, no. 6: 2182. https://doi.org/10.3390/ijms21062182

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop