Cell Fusion-Mediated Tissue Regeneration as an Inducer of Polyploidy and Aneuploidy
Abstract
1. Introduction
2. How Do Cells Fuse with Each Other?
3. Cell Fusion as an Inducer of Polyploidy, Aneuploidy, and Genomic Instability
4. What Is the Fate of Cell Fusion-Derived Aneuploid and Genomic Instable Hybrid Cells?
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
BMSC | bone marrow-derived stem cells |
HST | heterokaryon-to-synkaryon transition |
MSCs | mesenchymal stem/stromal cells |
HSCs | hematopoietic stem cells |
GFP | green fluorescent protein |
Fah | fumarylacetoacetate hydrolase |
NTBC | 2-(2-nitro-4-trifluoro-methylbenzoyl)-1,3-cyclohexanedione |
IL-4 | interleukin-4 |
RANKL | receptor activator of NF-κB ligand |
MMP-9 | matrix metallopeptidase 9 |
DC-STAMP | dendrocyte expressed seven transmembrane protein |
OC-STAMP | osteoclast stimulatory transmembrane protein |
TNF-α | tumor necrosis factor-α |
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Dörnen, J.; Sieler, M.; Weiler, J.; Keil, S.; Dittmar, T. Cell Fusion-Mediated Tissue Regeneration as an Inducer of Polyploidy and Aneuploidy. Int. J. Mol. Sci. 2020, 21, 1811. https://doi.org/10.3390/ijms21051811
Dörnen J, Sieler M, Weiler J, Keil S, Dittmar T. Cell Fusion-Mediated Tissue Regeneration as an Inducer of Polyploidy and Aneuploidy. International Journal of Molecular Sciences. 2020; 21(5):1811. https://doi.org/10.3390/ijms21051811
Chicago/Turabian StyleDörnen, Jessica, Mareike Sieler, Julian Weiler, Silvia Keil, and Thomas Dittmar. 2020. "Cell Fusion-Mediated Tissue Regeneration as an Inducer of Polyploidy and Aneuploidy" International Journal of Molecular Sciences 21, no. 5: 1811. https://doi.org/10.3390/ijms21051811
APA StyleDörnen, J., Sieler, M., Weiler, J., Keil, S., & Dittmar, T. (2020). Cell Fusion-Mediated Tissue Regeneration as an Inducer of Polyploidy and Aneuploidy. International Journal of Molecular Sciences, 21(5), 1811. https://doi.org/10.3390/ijms21051811