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Exosomes in Prostate Cancer Diagnosis, Prognosis and Therapy

1st Department of Clinical Radiology, Medical University of Warsaw, 02-004 Warsaw, Poland
Department of Biochemistry and Pharmacogenomics, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland
Centre for Preclinical Research, Medical University of Warsaw, 02-097 Warsaw, Poland
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(6), 2118;
Received: 28 February 2020 / Revised: 13 March 2020 / Accepted: 17 March 2020 / Published: 19 March 2020
(This article belongs to the Special Issue Extracellular Vesicles: Biology and Potentials in Cancer Therapeutics)
Prostate cancer (PCa) is the second most common cause of cancer-related mortality among men in the developed world. Conventional anti-PCa therapies are not effective for patients with advanced and/or metastatic disease. In most cases, cancer therapies fail due to an incomplete depletion of tumor cells, resulting in tumor relapse. Exosomes are involved in tumor progression, promoting the angiogenesis and migration of tumor cells during metastasis. These structures contribute to the dissemination of pathogenic agents through interaction with recipient cells. Exosomes may deliver molecules that are able to induce the transdifferentiation process, known as “epithelial to mesenchymal transition”. The composition of exosomes and the associated possibilities of interacting with cells make exosomes multifaceted regulators of cancer development. Extracellular vesicles have biophysical properties, such as stability, biocompatibility, permeability, low toxicity and low immunogenicity, which are key for the successful development of an innovative drug delivery system. They have an enhanced circulation stability and bio-barrier permeation ability, and they can therefore be used as effective chemotherapeutic carriers to improve the regulation of target tissues and organs. Exosomes have the capacity to deliver different types of cargo and to target specific cells. Chemotherapeutics, natural products and RNA have been encapsulated for the treatment of prostate cancers. View Full-Text
Keywords: extracellular vesicle; precision oncology; cancer biomarker; prostate cancer extracellular vesicle; precision oncology; cancer biomarker; prostate cancer
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MDPI and ACS Style

Lorenc, T.; Klimczyk, K.; Michalczewska, I.; Słomka, M.; Kubiak-Tomaszewska, G.; Olejarz, W. Exosomes in Prostate Cancer Diagnosis, Prognosis and Therapy. Int. J. Mol. Sci. 2020, 21, 2118.

AMA Style

Lorenc T, Klimczyk K, Michalczewska I, Słomka M, Kubiak-Tomaszewska G, Olejarz W. Exosomes in Prostate Cancer Diagnosis, Prognosis and Therapy. International Journal of Molecular Sciences. 2020; 21(6):2118.

Chicago/Turabian Style

Lorenc, Tomasz, Katarzyna Klimczyk, Izabela Michalczewska, Monika Słomka, Grażyna Kubiak-Tomaszewska, and Wioletta Olejarz. 2020. "Exosomes in Prostate Cancer Diagnosis, Prognosis and Therapy" International Journal of Molecular Sciences 21, no. 6: 2118.

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