Physiologic Events of Embryo Implantation and Decidualization in Human and Non-Human Primates
1
Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, Grand Rapids, MI 49503, USA
2
Department of Animal Science, Michigan State University, East Lansing, MI 48824, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(6), 1973; https://doi.org/10.3390/ijms21061973
Received: 3 February 2020
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Revised: 10 March 2020
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Accepted: 11 March 2020
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Published: 13 March 2020
(This article belongs to the Special Issue Embryo-Maternal Interactions Underlying Reproduction in Mammals)
Reproduction is a fundamental process for the preservation of the human species. This process requires a sequence of orchestrated events that are necessary for a successful pregnancy. Two of the most critical steps in the establishment of human pregnancy are implantation and decidualization, which are required for maternal interactions with the developing embryo. This review primarily highlights the physiological aspects of these two events and the adverse pregnancy outcomes from defective implantation and decidualization. The focus of this review is to provide a general concept of the mechanisms involved during the window of implantation, description of components involved in the process and possible pathologies that could disrupt the embryo implantation and decidualization and specifically as it applies to women and non-human primates.
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Keywords:
cytokines; decidualization; embryo; endometrium; gynecological pathologies; implantation; miRNA; Notch; primates
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MDPI and ACS Style
Ochoa-Bernal, M.A.; Fazleabas, A.T. Physiologic Events of Embryo Implantation and Decidualization in Human and Non-Human Primates. Int. J. Mol. Sci. 2020, 21, 1973. https://doi.org/10.3390/ijms21061973
AMA Style
Ochoa-Bernal MA, Fazleabas AT. Physiologic Events of Embryo Implantation and Decidualization in Human and Non-Human Primates. International Journal of Molecular Sciences. 2020; 21(6):1973. https://doi.org/10.3390/ijms21061973
Chicago/Turabian StyleOchoa-Bernal, Maria A., and Asgerally T. Fazleabas. 2020. "Physiologic Events of Embryo Implantation and Decidualization in Human and Non-Human Primates" International Journal of Molecular Sciences 21, no. 6: 1973. https://doi.org/10.3390/ijms21061973
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