Next Article in Journal
Blood Metabolite Signature of Metabolic Syndrome Implicates Alterations in Amino Acid Metabolism: Findings from the Baltimore Longitudinal Study of Aging (BLSA) and the Tsuruoka Metabolomics Cohort Study (TMCS)
Previous Article in Journal
Immunoglobulin Abnormalities in Gaucher Disease: an Analysis of 278 Patients Included in the French Gaucher Disease Registry
Previous Article in Special Issue
Mechanistic Insight of Na/K-ATPase Signaling and HO-1 into Models of Obesity and Nonalcoholic Steatohepatitis
Open AccessReview

The Redox-Sensitive Na/K-ATPase Signaling in Uremic Cardiomyopathy

1
Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA
2
Department of Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(4), 1256; https://doi.org/10.3390/ijms21041256
Received: 21 January 2020 / Revised: 10 February 2020 / Accepted: 10 February 2020 / Published: 13 February 2020
(This article belongs to the Special Issue Redox Regulation of Cardiovascular Metabolism and Inflammation)
In recent years, Na/K-ATPase signaling has been implicated in different physiological and pathophysiological conditions, including cardiac hypertrophy and uremic cardiomyopathy. Cardiotonic steroids (CTS), specific ligands of Na/K-ATPase, regulate its enzymatic activity (at higher concentrations) and signaling function (at lower concentrations without significantly affecting its enzymatic activity) and increase reactive oxygen species (ROS) generation. On the other hand, an increase in ROS alone also regulates the Na/K-ATPase enzymatic activity and signaling function. We termed this phenomenon the Na/K-ATPase-mediated oxidant-amplification loop, in which oxidative stress regulates both the Na/K-ATPase activity and signaling. Most recently, we also demonstrated that this amplification loop is involved in the development of uremic cardiomyopathy. This review aims to evaluate the redox-sensitive Na/K-ATPase-mediated oxidant amplification loop and uremic cardiomyopathy. View Full-Text
Keywords: Na/K-ATPase; signaling; c-Src. ROS; partial (5/6th) nephrectomy; uremic cardiomyopathy Na/K-ATPase; signaling; c-Src. ROS; partial (5/6th) nephrectomy; uremic cardiomyopathy
Show Figures

Graphical abstract

MDPI and ACS Style

Liu, J.; Nie, Y.; Chaudhry, M.; Bai, F.; Chuang, J.; Sodhi, K.; Shapiro, J.I. The Redox-Sensitive Na/K-ATPase Signaling in Uremic Cardiomyopathy. Int. J. Mol. Sci. 2020, 21, 1256.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop