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Keywords = partial (5/6th) nephrectomy

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14 pages, 1337 KB  
Review
The Redox-Sensitive Na/K-ATPase Signaling in Uremic Cardiomyopathy
by Jiang Liu, Ying Nie, Muhammad Chaudhry, Fang Bai, Justin Chuang, Komal Sodhi and Joseph I. Shapiro
Int. J. Mol. Sci. 2020, 21(4), 1256; https://doi.org/10.3390/ijms21041256 - 13 Feb 2020
Cited by 23 | Viewed by 4827
Abstract
In recent years, Na/K-ATPase signaling has been implicated in different physiological and pathophysiological conditions, including cardiac hypertrophy and uremic cardiomyopathy. Cardiotonic steroids (CTS), specific ligands of Na/K-ATPase, regulate its enzymatic activity (at higher concentrations) and signaling function (at lower concentrations without significantly affecting [...] Read more.
In recent years, Na/K-ATPase signaling has been implicated in different physiological and pathophysiological conditions, including cardiac hypertrophy and uremic cardiomyopathy. Cardiotonic steroids (CTS), specific ligands of Na/K-ATPase, regulate its enzymatic activity (at higher concentrations) and signaling function (at lower concentrations without significantly affecting its enzymatic activity) and increase reactive oxygen species (ROS) generation. On the other hand, an increase in ROS alone also regulates the Na/K-ATPase enzymatic activity and signaling function. We termed this phenomenon the Na/K-ATPase-mediated oxidant-amplification loop, in which oxidative stress regulates both the Na/K-ATPase activity and signaling. Most recently, we also demonstrated that this amplification loop is involved in the development of uremic cardiomyopathy. This review aims to evaluate the redox-sensitive Na/K-ATPase-mediated oxidant amplification loop and uremic cardiomyopathy. Full article
(This article belongs to the Special Issue Redox Regulation of Cardiovascular Metabolism and Inflammation)
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