Next Article in Journal
A Novel Quantitative Approach to Staging and Assessing Recovery from Type 1 Diabetes Mellitus: The Type 1 Diabetes Mellitus Metabolic Recovery Index
Next Article in Special Issue
A Molecular Basis for Reciprocal Regulation between Pheromones and Hormones in Response to Dietary Cues in C. elegans
Previous Article in Journal
Engineering Biology to Construct Microbial Chassis for the Production of Difficult-to-Express Proteins
ijms-logo
Article Menu

Article Menu

Open AccessArticle

Antidiabetic Effects of Bisamide Derivative of Dicarboxylic Acid in Metabolic Disorders

1
Laboratory of Regenerative Pharmacology, Goldberg ED Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre of the Russian Academy of Sciences, Lenin, 3, 634028 Tomsk, Russia
2
Obschestvo s ogranichennoi otvetstvennostiyu “PHARMENTERPRISES”, 143026 Moscow, Russia
3
Department of Pharmacology, Siberian State Medical University, 634050 Tomsk, Russia
4
Stem Cell Biology and Regenerative Medicine Group, School of Pharmacy, University of Reading, Whiteknights campus, Reading RG6 6UB, UK
5
Periodontology, Department of Dental Medicine, Faculty of Health, University of Witten/Herdecke, Alfred-Herrhausen-Straße 50, 58 448 Witten, Germany
6
Biology Department, Military Medical Academy, 199004 Saint-Petersburg, Russia
7
Cardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences, 634012 Tomsk, Russia
8
Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(3), 991; https://doi.org/10.3390/ijms21030991
Received: 21 January 2020 / Revised: 31 January 2020 / Accepted: 31 January 2020 / Published: 3 February 2020
(This article belongs to the Special Issue Central and Peripheral Molecular Mechanisms of Metabolism Regulation)
In clinical practice, the metabolic syndrome can lead to multiple complications, including diabetes. It remains unclear which component of the metabolic syndrome (obesity, inflammation, hyperglycemia, or insulin resistance) has the strongest inhibitory effect on stem cells involved in beta cell regeneration. This makes it challenging to develop effective treatment options for complications such as diabetes. In our study, experiments were performed on male C57BL/6 mice where metabolic disorders have been introduced experimentally by a combination of streptozotocin-treatment and a high-fat diet. We evaluated the biological effects of Bisamide Derivative of Dicarboxylic Acid (BDDA) and its impact on pancreatic stem cells in vivo. To assess the impact of BDDA, we applied a combination of histological and biochemical methods along with a cytometric analysis of stem cell and progenitor cell markers. We show that in mice with metabolic disorders, BDDA has a positive effect on lipid and glucose metabolism. The pancreatic restoration was associated with a decrease of the inhibitory effects of inflammation and obesity factors on pancreatic stem cells. Our data shows that BDDA increases the number of pancreatic stem cells. Thus, BDDA could be used as a new compound for treating complication of the metabolic syndrome such as diabetes. View Full-Text
Keywords: metabolic disorders; diabetes; tissue-specific stem cells; Bisamide Derivative of Dicarboxylic Acid; regeneration metabolic disorders; diabetes; tissue-specific stem cells; Bisamide Derivative of Dicarboxylic Acid; regeneration
Show Figures

Figure 1

MDPI and ACS Style

Pakhomova, A.V.; Nebolsin, V.E.; Pershina, O.V.; Krupin, V.A.; Sandrikina, L.A.; Pan, E.S.; Ermakova, N.N.; Vaizova, O.E.; Widera, D.; Grimm, W.-D.; Kravtsov, V.Y.; Afanasiev, S.A.; Morozov, S.G.; Kubatiev, A.A.; Dygai, A.M.; Skurikhin, E.G. Antidiabetic Effects of Bisamide Derivative of Dicarboxylic Acid in Metabolic Disorders. Int. J. Mol. Sci. 2020, 21, 991. https://doi.org/10.3390/ijms21030991

AMA Style

Pakhomova AV, Nebolsin VE, Pershina OV, Krupin VA, Sandrikina LA, Pan ES, Ermakova NN, Vaizova OE, Widera D, Grimm W-D, Kravtsov VY, Afanasiev SA, Morozov SG, Kubatiev AA, Dygai AM, Skurikhin EG. Antidiabetic Effects of Bisamide Derivative of Dicarboxylic Acid in Metabolic Disorders. International Journal of Molecular Sciences. 2020; 21(3):991. https://doi.org/10.3390/ijms21030991

Chicago/Turabian Style

Pakhomova, Angelina V.; Nebolsin, Vladimir E.; Pershina, Olga V.; Krupin, Vyacheslav A.; Sandrikina, Lubov A.; Pan, Edgar S.; Ermakova, Natalia N.; Vaizova, Olga E.; Widera, Darius; Grimm, Wolf-Dieter; Kravtsov, Viacheslav Y.; Afanasiev, Sergey A.; Morozov, Sergey G.; Kubatiev, Aslan A.; Dygai, Alexander M.; Skurikhin, Evgenii G. 2020. "Antidiabetic Effects of Bisamide Derivative of Dicarboxylic Acid in Metabolic Disorders" Int. J. Mol. Sci. 21, no. 3: 991. https://doi.org/10.3390/ijms21030991

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop