Antidiabetic Effects of Bisamide Derivative of Dicarboxylic Acid in Metabolic Disorders

Pakhomova, Angelina Vladimirovna; Nebolsin, Vladimir Evgenievich; Pershina, Olga Victorovna; Krupin, Vyacheslav Andreevich; Sandrikina, Lubov Alexandrovna; Pan, Edgar Sergeevich; Ermakova, Natalia Nicolaevna; Vaizova, Olga Evgenevna; Widera, Darius; Grimm, Wolf-Dieter; Kravtsov, Viacheslav Yur’evich; Afanasiev, Sergey Alexandrovich; Morozov, Sergey Georgievich; Kubatiev, Aslan Amirkhanovich; Dygai, Alexander Mikhaylovich; Skurikhin, Evgenii Germanovich

doi:10.3390/ijms21030991

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Antidiabetic Effects of Bisamide Derivative of Dicarboxylic Acid in Metabolic Disorders

Laboratory of Regenerative Pharmacology, Goldberg ED Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre of the Russian Academy of Sciences, Lenin, 3, 634028 Tomsk, Russia

Obschestvo s ogranichennoi otvetstvennostiyu “PHARMENTERPRISES”, 143026 Moscow, Russia

Department of Pharmacology, Siberian State Medical University, 634050 Tomsk, Russia

⁴

Stem Cell Biology and Regenerative Medicine Group, School of Pharmacy, University of Reading, Whiteknights campus, Reading RG6 6UB, UK

⁵

Periodontology, Department of Dental Medicine, Faculty of Health, University of Witten/Herdecke, Alfred-Herrhausen-Straße 50, 58 448 Witten, Germany

⁶

Biology Department, Military Medical Academy, 199004 Saint-Petersburg, Russia

⁷

Cardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences, 634012 Tomsk, Russia

⁸

Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2020, 21(3), 991; https://doi.org/10.3390/ijms21030991

Received: 21 January 2020 / Revised: 31 January 2020 / Accepted: 31 January 2020 / Published: 3 February 2020

(This article belongs to the Special Issue Central and Peripheral Molecular Mechanisms of Metabolism Regulation)

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Abstract

In clinical practice, the metabolic syndrome can lead to multiple complications, including diabetes. It remains unclear which component of the metabolic syndrome (obesity, inflammation, hyperglycemia, or insulin resistance) has the strongest inhibitory effect on stem cells involved in beta cell regeneration. This makes it challenging to develop effective treatment options for complications such as diabetes. In our study, experiments were performed on male C57BL/6 mice where metabolic disorders have been introduced experimentally by a combination of streptozotocin-treatment and a high-fat diet. We evaluated the biological effects of Bisamide Derivative of Dicarboxylic Acid (BDDA) and its impact on pancreatic stem cells in vivo. To assess the impact of BDDA, we applied a combination of histological and biochemical methods along with a cytometric analysis of stem cell and progenitor cell markers. We show that in mice with metabolic disorders, BDDA has a positive effect on lipid and glucose metabolism. The pancreatic restoration was associated with a decrease of the inhibitory effects of inflammation and obesity factors on pancreatic stem cells. Our data shows that BDDA increases the number of pancreatic stem cells. Thus, BDDA could be used as a new compound for treating complication of the metabolic syndrome such as diabetes. View Full-Text

Keywords: metabolic disorders; diabetes; tissue-specific stem cells; Bisamide Derivative of Dicarboxylic Acid; regeneration

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MDPI and ACS Style

Pakhomova, A.V.; Nebolsin, V.E.; Pershina, O.V.; Krupin, V.A.; Sandrikina, L.A.; Pan, E.S.; Ermakova, N.N.; Vaizova, O.E.; Widera, D.; Grimm, W.-D.; Kravtsov, V.Y.; Afanasiev, S.A.; Morozov, S.G.; Kubatiev, A.A.; Dygai, A.M.; Skurikhin, E.G. Antidiabetic Effects of Bisamide Derivative of Dicarboxylic Acid in Metabolic Disorders. Int. J. Mol. Sci. 2020, 21, 991. https://doi.org/10.3390/ijms21030991

AMA Style

Pakhomova AV, Nebolsin VE, Pershina OV, Krupin VA, Sandrikina LA, Pan ES, Ermakova NN, Vaizova OE, Widera D, Grimm W-D, Kravtsov VY, Afanasiev SA, Morozov SG, Kubatiev AA, Dygai AM, Skurikhin EG. Antidiabetic Effects of Bisamide Derivative of Dicarboxylic Acid in Metabolic Disorders. International Journal of Molecular Sciences. 2020; 21(3):991. https://doi.org/10.3390/ijms21030991

Chicago/Turabian Style

Pakhomova, Angelina V., Vladimir E. Nebolsin, Olga V. Pershina, Vyacheslav A. Krupin, Lubov A. Sandrikina, Edgar S. Pan, Natalia N. Ermakova, Olga E. Vaizova, Darius Widera, Wolf-Dieter Grimm, Viacheslav Y. Kravtsov, Sergey A. Afanasiev, Sergey G. Morozov, Aslan A. Kubatiev, Alexander M. Dygai, and Evgenii G. Skurikhin. 2020. "Antidiabetic Effects of Bisamide Derivative of Dicarboxylic Acid in Metabolic Disorders" International Journal of Molecular Sciences 21, no. 3: 991. https://doi.org/10.3390/ijms21030991

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Antidiabetic Effects of Bisamide Derivative of Dicarboxylic Acid in Metabolic Disorders

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