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Open AccessArticle

Environmental Enrichment: Disentangling the Influence of Novelty, Social, and Physical Activity on Cerebral Amyloid Angiopathy in a Transgenic Mouse Model

1
Department of Psychology, Stony Brook University, 100 Nicolls Road, Stony Brook, NY 11794, USA
2
Department of Neuroscience and Experimental Therapeutics, Albany Medical College, 47 New Scotland Ave, Albany, NY 12208, USA
3
George & Anne Ryan Institute for Neuroscience, 130 Flagg Road, University of Rhode Island, Kingston, RI 02881, USA
4
Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, 700 Butler Drive, Providence, RI 02906, USA
5
Department of Psychology, Farmingdale State College, 2350 Broadhollow Rd, Farmingdale, NY 11735, USA
6
Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
7
Department of Psychology, University of Rhode Island, Kingston, RI 02881, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(3), 843; https://doi.org/10.3390/ijms21030843
Received: 2 January 2020 / Revised: 23 January 2020 / Accepted: 26 January 2020 / Published: 28 January 2020
(This article belongs to the Special Issue Cerebral Amyloid Angiopathy: Causes, Diagnosis and Treatment)
Cerebral amyloid angiopathy (CAA) is the deposition of amyloid protein in the cerebral vasculature, a common feature in both aging and Alzheimer’s disease (AD). However, the effects of environmental factors, particularly cognitive stimulation, social stimulation, and physical activity, on CAA pathology are poorly understood. These factors, delivered in the form of the environmental enrichment (EE) paradigm in rodents, have been shown to have beneficial effects on the brain and behavior in healthy aging and AD models. However, the relative importance of these subcomponents on CAA pathology has not been investigated. Therefore, we assessed the effects of EE, social enrichment (SOC), and cognitive enrichment (COG) compared to a control group that was single housed without enrichment (SIN) from 4 to 8 months of age in wild-type mice (WT) and Tg-SwDI mice, a transgenic mouse model of CAA that exhibits cognitive/behavioral deficits. The results show that individual facets of enrichment can affect an animal model of CAA, though the SOC and combined EE conditions are generally the most effective at producing physiological, cognitive/behavioral, and neuropathological changes, adding to a growing literature supporting the benefits of lifestyle interventions. View Full-Text
Keywords: cerebral amyloid angiopathy; Alzheimer’s disease; enriched environment; exercise; reserve; resilience cerebral amyloid angiopathy; Alzheimer’s disease; enriched environment; exercise; reserve; resilience
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MDPI and ACS Style

Robison, L.S.; Francis, N.; Popescu, D.L.; Anderson, M.E.; Hatfield, J.; Xu, F.; Anderson, B.J.; Van Nostrand, W.E.; Robinson, J.K. Environmental Enrichment: Disentangling the Influence of Novelty, Social, and Physical Activity on Cerebral Amyloid Angiopathy in a Transgenic Mouse Model. Int. J. Mol. Sci. 2020, 21, 843. https://doi.org/10.3390/ijms21030843

AMA Style

Robison LS, Francis N, Popescu DL, Anderson ME, Hatfield J, Xu F, Anderson BJ, Van Nostrand WE, Robinson JK. Environmental Enrichment: Disentangling the Influence of Novelty, Social, and Physical Activity on Cerebral Amyloid Angiopathy in a Transgenic Mouse Model. International Journal of Molecular Sciences. 2020; 21(3):843. https://doi.org/10.3390/ijms21030843

Chicago/Turabian Style

Robison, Lisa S.; Francis, Nikita; Popescu, Dominique L.; Anderson, Maria E.; Hatfield, Joshua; Xu, Feng; Anderson, Brenda J.; Van Nostrand, William E.; Robinson, John K. 2020. "Environmental Enrichment: Disentangling the Influence of Novelty, Social, and Physical Activity on Cerebral Amyloid Angiopathy in a Transgenic Mouse Model" Int. J. Mol. Sci. 21, no. 3: 843. https://doi.org/10.3390/ijms21030843

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