Next Article in Journal
Revisiting the Interaction of Melittin with Phospholipid Bilayers: The Effects of Concentration and Ionic Strength
Next Article in Special Issue
The Added Value of Diagnostic and Theranostic PET Imaging for the Treatment of CNS Tumors
Previous Article in Journal
Constitutive Activation of Guanylate Cyclase by the G86R GCAP1 Variant Is Due to “Locking” Cation-π Interactions that Impair the Activator-to-Inhibitor Structural Transition
Previous Article in Special Issue
Dissecting Molecular Features of Gliomas: Genetic Loci and Validated Biomarkers
Open AccessReview

NTRK Fusions in Central Nervous System Tumors: A Rare, but Worthy Target

1
Pathology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, Italy
2
Pathology Unit, Department of Oncology, University of Turin, 10126 Turin, Italy
3
Pediatric Onco-Hematology Unit, Department of Pediatric and Public Health Sciences, University of Turin, 10126 Turin, Italy
4
Neurosurgery Unit, Department of Neurosciences, University of Turin, 10126 Turin, Italy
5
Department of Neuro-Oncology, University and City of Health and Science Hospital, 10126 Turin, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(3), 753; https://doi.org/10.3390/ijms21030753
Received: 30 December 2019 / Revised: 20 January 2020 / Accepted: 21 January 2020 / Published: 23 January 2020
(This article belongs to the Special Issue Molecular Biology of Brain Tumors)
The neurotrophic tropomyosin receptor kinase (NTRK) genes (NTRK1, NTRK2, and NTRK3) code for three transmembrane high-affinity tyrosine-kinase receptors for nerve growth factors (TRK-A, TRK-B, and TRK-C) which are mainly involved in nervous system development. Loss of function alterations in these genes can lead to nervous system development problems; conversely, activating alterations harbor oncogenic potential, promoting cell proliferation/survival and tumorigenesis. Chromosomal rearrangements are the most clinically relevant alterations of pathological NTRK activation, leading to constitutionally active chimeric receptors. NTRK fusions have been detected with extremely variable frequencies in many pediatric and adult cancer types, including central nervous system (CNS) tumors. These alterations can be detected by different laboratory assays (e.g., immunohistochemistry, FISH, sequencing), but each of these approaches has specific advantages and limitations which must be taken into account for an appropriate use in diagnostics or research. Moreover, therapeutic targeting of this molecular marker recently showed extreme efficacy. Considering the overall lack of effective treatments for brain neoplasms, it is expected that detection of NTRK fusions will soon become a mainstay in the diagnostic assessment of CNS tumors, and thus in-depth knowledge regarding this topic is warranted. View Full-Text
Keywords: central nervous system; glioma; pediatric tumors; molecular pathology; NTRK; gene fusion; targeted therapies; precision medicine central nervous system; glioma; pediatric tumors; molecular pathology; NTRK; gene fusion; targeted therapies; precision medicine
Show Figures

Figure 1

MDPI and ACS Style

Gambella, A.; Senetta, R.; Collemi, G.; Vallero, S.G.; Monticelli, M.; Cofano, F.; Zeppa, P.; Garbossa, D.; Pellerino, A.; Rudà, R.; Soffietti, R.; Fagioli, F.; Papotti, M.; Cassoni, P.; Bertero, L. NTRK Fusions in Central Nervous System Tumors: A Rare, but Worthy Target. Int. J. Mol. Sci. 2020, 21, 753. https://doi.org/10.3390/ijms21030753

AMA Style

Gambella A, Senetta R, Collemi G, Vallero SG, Monticelli M, Cofano F, Zeppa P, Garbossa D, Pellerino A, Rudà R, Soffietti R, Fagioli F, Papotti M, Cassoni P, Bertero L. NTRK Fusions in Central Nervous System Tumors: A Rare, but Worthy Target. International Journal of Molecular Sciences. 2020; 21(3):753. https://doi.org/10.3390/ijms21030753

Chicago/Turabian Style

Gambella, Alessandro; Senetta, Rebecca; Collemi, Giammarco; Vallero, Stefano G.; Monticelli, Matteo; Cofano, Fabio; Zeppa, Pietro; Garbossa, Diego; Pellerino, Alessia; Rudà, Roberta; Soffietti, Riccardo; Fagioli, Franca; Papotti, Mauro; Cassoni, Paola; Bertero, Luca. 2020. "NTRK Fusions in Central Nervous System Tumors: A Rare, but Worthy Target" Int. J. Mol. Sci. 21, no. 3: 753. https://doi.org/10.3390/ijms21030753

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop