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Bisphenol A (BPA)-Induced Changes in the Number of Serotonin-Positive Cells in the Mucosal Layer of Porcine Small Intestine—the Preliminary Studies

Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowski Str. 13, 10-718 Olsztyn, Poland
Int. J. Mol. Sci. 2020, 21(3), 1079; https://doi.org/10.3390/ijms21031079
Received: 15 January 2020 / Revised: 2 February 2020 / Accepted: 4 February 2020 / Published: 6 February 2020
(This article belongs to the Special Issue Serotonin in Health and Disease)
Bisphenol A (BPA) is a substance used in the production of plastics which has a negative impact on many internal organs. Because BPA is normally toxic for the gastrointestinal (GI) tract, the intestine is especially vulnerable to the adverse effects of this substance. The aim of this investigation was to study the influence of two doses of BPA (0.05 mg and 0.5 mg/kg body weight/day) on the number of mucosal cells in the porcine small intestine and containing serotonin (5-hydroxytryptamine, 5-HT). During the experiment, it was demonstrated that both applied BPA doses caused an increase in the number of 5-HT-positive cells located in the mucosal layer of the duodenum, jejunum, and ileum. These changes may be connected with the direct impact of BPA on the intestinal mucosa, the pro-inflammatory and immunomodulatory properties of this substance, and/or the influence of BPA on the neurochemical characterization of nervous structures supplying the intestine. View Full-Text
Keywords: bisphenol A; serotonin; small intestine; pig bisphenol A; serotonin; small intestine; pig
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MDPI and ACS Style

Gonkowski, S. Bisphenol A (BPA)-Induced Changes in the Number of Serotonin-Positive Cells in the Mucosal Layer of Porcine Small Intestine—the Preliminary Studies. Int. J. Mol. Sci. 2020, 21, 1079. https://doi.org/10.3390/ijms21031079

AMA Style

Gonkowski S. Bisphenol A (BPA)-Induced Changes in the Number of Serotonin-Positive Cells in the Mucosal Layer of Porcine Small Intestine—the Preliminary Studies. International Journal of Molecular Sciences. 2020; 21(3):1079. https://doi.org/10.3390/ijms21031079

Chicago/Turabian Style

Gonkowski, Slawomir. 2020. "Bisphenol A (BPA)-Induced Changes in the Number of Serotonin-Positive Cells in the Mucosal Layer of Porcine Small Intestine—the Preliminary Studies" International Journal of Molecular Sciences 21, no. 3: 1079. https://doi.org/10.3390/ijms21031079

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