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Article

Early CSF Biomarkers and Late Functional Outcomes in Spinal Cord Injury. A Pilot Study

1
Spinal Unit, Montecatone Rehabilitation Institute, 40026 Imola, Italy
2
Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano Emilia, Italy
3
Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy
4
Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy
5
IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy
6
Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy
7
Ciri-SDV, University of Bologna, 40126 Bologna, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(23), 9037; https://doi.org/10.3390/ijms21239037
Received: 29 October 2020 / Revised: 18 November 2020 / Accepted: 20 November 2020 / Published: 27 November 2020
(This article belongs to the Special Issue Peripheral Biomarkers in Neurodegenerative Diseases 2.0)
Although, biomarkers are regarded as an important tool for monitoring injury severity and treatment efficacy, and for predicting clinical evolution in many neurological diseases and disorders including spinal cord injury, there is still a lack of reliable biomarkers for the assessment of clinical course and patient outcome. In this study, a biological dataset of 60 cytokines/chemokines, growth factorsm and intracellular and extracellular matrix proteins, analyzed in CSF within 24 h of injury, was used for correlation analysis with the clinical dataset of the same patients. A heat map was generated of positive and negative correlations between biomarkers and clinical rating scale scores at discharge, and between biomarkers and changes in clinical scores during the observation period. Using very stringent statistical criteria, we found 10 molecules which correlated with clinical scores at discharge, and five molecules, which correlated with changes in clinical scores. The proposed methodology may be useful for generating hypotheses regarding “predictive” and “treatment effectiveness” biomarkers, thereby suggesting potential candidates for disease-modifying therapies using a “bed-to-bench” approach. View Full-Text
Keywords: spinal cord injury; CSF; biomarkers; clinical scales spinal cord injury; CSF; biomarkers; clinical scales
MDPI and ACS Style

Capirossi, R.; Piunti, B.; Fernández, M.; Maietti, E.; Rucci, P.; Negrini, S.; Giovannini, T.; Kiekens, C.; Calzà, L. Early CSF Biomarkers and Late Functional Outcomes in Spinal Cord Injury. A Pilot Study. Int. J. Mol. Sci. 2020, 21, 9037. https://doi.org/10.3390/ijms21239037

AMA Style

Capirossi R, Piunti B, Fernández M, Maietti E, Rucci P, Negrini S, Giovannini T, Kiekens C, Calzà L. Early CSF Biomarkers and Late Functional Outcomes in Spinal Cord Injury. A Pilot Study. International Journal of Molecular Sciences. 2020; 21(23):9037. https://doi.org/10.3390/ijms21239037

Chicago/Turabian Style

Capirossi, Rita, Beatrice Piunti, Mercedes Fernández, Elisa Maietti, Paola Rucci, Stefano Negrini, Tiziana Giovannini, Carlotte Kiekens, and Laura Calzà. 2020. "Early CSF Biomarkers and Late Functional Outcomes in Spinal Cord Injury. A Pilot Study" International Journal of Molecular Sciences 21, no. 23: 9037. https://doi.org/10.3390/ijms21239037

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