JAK/STAT Activation: A General Mechanism for Bone Development, Homeostasis, and Regeneration

Damerau, Alexandra; Gaber, Timo; Ohrndorf, Sarah; Hoff, Paula

doi:10.3390/ijms21239004

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JAK/STAT Activation: A General Mechanism for Bone Development, Homeostasis, and Regeneration

¹

Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, 10117 Berlin, Germany

²

German Rheumatism Research Centre (DRFZ) Berlin, a Leibniz Institute, 10117 Berlin, Germany

³

Endokrinologikum Berlin am Gendarmenmarkt, 10117 Berlin, Germany

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2020, 21(23), 9004; https://doi.org/10.3390/ijms21239004

Submission received: 31 October 2020 / Revised: 20 November 2020 / Accepted: 24 November 2020 / Published: 26 November 2020

(This article belongs to the Special Issue Recent Advances in Mesenchymal Stem Cell Immunomodulation and Regenerative Medicine 2.0)

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Abstract

The Janus kinase (JAK) signal transducer and activator of transcription (STAT) signaling pathway serves as an important downstream mediator for a variety of cytokines, hormones, and growth factors. Emerging evidence suggests JAK/STAT signaling pathway plays an important role in bone development, metabolism, and healing. In this light, pro-inflammatory cytokines are now clearly implicated in these processes as they can perturb normal bone remodeling through their action on osteoclasts and osteoblasts at both intra- and extra-articular skeletal sites. Here, we summarize the role of JAK/STAT pathway on development, homeostasis, and regeneration based on skeletal phenotype of individual JAK and STAT gene knockout models and selective inhibition of components of the JAK/STAT signaling including influences of JAK inhibition in osteoclasts, osteoblasts, and osteocytes.

Keywords: JAK/STAT; osteoblast; osteoclast; bone development; homeostasis; osteoporosis

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MDPI and ACS Style

Damerau, A.; Gaber, T.; Ohrndorf, S.; Hoff, P. JAK/STAT Activation: A General Mechanism for Bone Development, Homeostasis, and Regeneration. Int. J. Mol. Sci. 2020, 21, 9004. https://doi.org/10.3390/ijms21239004

AMA Style

Damerau A, Gaber T, Ohrndorf S, Hoff P. JAK/STAT Activation: A General Mechanism for Bone Development, Homeostasis, and Regeneration. International Journal of Molecular Sciences. 2020; 21(23):9004. https://doi.org/10.3390/ijms21239004

Chicago/Turabian Style

Damerau, Alexandra, Timo Gaber, Sarah Ohrndorf, and Paula Hoff. 2020. "JAK/STAT Activation: A General Mechanism for Bone Development, Homeostasis, and Regeneration" International Journal of Molecular Sciences 21, no. 23: 9004. https://doi.org/10.3390/ijms21239004

APA Style

Damerau, A., Gaber, T., Ohrndorf, S., & Hoff, P. (2020). JAK/STAT Activation: A General Mechanism for Bone Development, Homeostasis, and Regeneration. International Journal of Molecular Sciences, 21(23), 9004. https://doi.org/10.3390/ijms21239004

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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JAK/STAT Activation: A General Mechanism for Bone Development, Homeostasis, and Regeneration

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