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Extracellular Vesicles, Influential Players of Intercellular Communication within Adult Neurogenic Niches

Laboratory of Neuroplasticity, Department of Pharmaceutical Sciences, University of Piemonte Orientale, 28100 Novara, Italy
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Int. J. Mol. Sci. 2020, 21(22), 8819; https://doi.org/10.3390/ijms21228819
Received: 19 October 2020 / Revised: 18 November 2020 / Accepted: 19 November 2020 / Published: 21 November 2020
(This article belongs to the Special Issue Mechanism of Adult Neurogenesis)
Adult neurogenesis, involving the generation of functional neurons from adult neural stem cells (NSCs), occurs constitutively in discrete brain regions such as hippocampus, sub-ventricular zone (SVZ) and hypothalamus. The intrinsic structural plasticity of the neurogenic process allows the adult brain to face the continuously changing external and internal environment and requires coordinated interplay between all cell types within the specialized microenvironment of the neurogenic niche. NSC-, neuronal- and glia-derived factors, originating locally, regulate the balance between quiescence and self-renewal of NSC, their differentiation programs and the survival and integration of newborn cells. Extracellular Vesicles (EVs) are emerging as important mediators of cell-to-cell communication, representing an efficient way to transfer the biologically active cargos (nucleic acids, proteins, lipids) by which they modulate the function of the recipient cells. Current knowledge of the physiological role of EVs within adult neurogenic niches is rather limited. In this review, we will summarize and discuss EV-based cross-talk within adult neurogenic niches and postulate how EVs might play a critical role in the regulation of the neurogenic process. View Full-Text
Keywords: adult neurogenesis; extracellular vesicles; neural stem cell; neuron; astrocyte; microglia adult neurogenesis; extracellular vesicles; neural stem cell; neuron; astrocyte; microglia
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Losurdo, M.; Grilli, M. Extracellular Vesicles, Influential Players of Intercellular Communication within Adult Neurogenic Niches. Int. J. Mol. Sci. 2020, 21, 8819.

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