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Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities

1
Department of Epidemiology and Prevention, IRCCS NEUROMED, 86077 Pozzilli, Italy
2
Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, University of Leuven, 3000 Leuven, Belgium
3
Department of Medicine and Surgery, University of Insubria, 21100 Varese, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(22), 8817; https://doi.org/10.3390/ijms21228817
Received: 21 October 2020 / Revised: 18 November 2020 / Accepted: 19 November 2020 / Published: 21 November 2020
(This article belongs to the Special Issue Advances in Biological Functions of Platelet)
Alongside their function in primary haemostasis and thrombo-inflammation, platelets are increasingly considered a bridge between mental, immunological and coagulation-related disorders. This review focuses on the link between platelets and the pathophysiology of major depressive disorder (MDD) and its most frequent comorbidities. Platelet- and neuron-shared proteins involved in MDD are functionally described. Platelet-related studies performed in the context of MDD, cardiovascular disease, and major neurodegenerative, neuropsychiatric and neurodevelopmental disorders are transversally presented from an epidemiological, genetic and functional point of view. To provide a complete scenario, we report the analysis of original data on the epidemiological link between platelets and depression symptoms suggesting moderating and interactive effects of sex on this association. Epidemiological and genetic studies discussed suggest that blood platelets might also be relevant biomarkers of MDD prediction and occurrence in the context of MDD comorbidities. Finally, this review has the ambition to formulate some directives and perspectives for future research on this topic. View Full-Text
Keywords: depression; platelets; cardiovascular disease; psychiatric comorbidities; neurodegenerative disorders; platelet distribution width; gender depression; platelets; cardiovascular disease; psychiatric comorbidities; neurodegenerative disorders; platelet distribution width; gender
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Izzi, B.; Tirozzi, A.; Cerletti, C.; Donati, M.B.; de Gaetano, G.; Hoylaerts, M.F.; Iacoviello, L.; Gialluisi, A. Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities. Int. J. Mol. Sci. 2020, 21, 8817.

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