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The Potential Role of Hepatocyte Growth Factor in Degenerative Disorders of the Synovial Joint and Spine

Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
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Int. J. Mol. Sci. 2020, 21(22), 8717; https://doi.org/10.3390/ijms21228717
Received: 30 September 2020 / Revised: 30 October 2020 / Accepted: 16 November 2020 / Published: 18 November 2020
(This article belongs to the Special Issue Hepatocyte Growth Factor (HGF), II)
This paper aims to provide a comprehensive review of the changing role of hepatocyte growth factor (HGF) signaling in the healthy and diseased synovial joint and spine. HGF is a multifunctional growth factor that, like its specific receptor c-Met, is widely expressed in several bone and joint tissues. HGF has profound effects on cell survival and proliferation, matrix metabolism, inflammatory response, and neurotrophic action. HGF plays an important role in normal bone and cartilage turnover. Changes in HGF/c-Met have also been linked to pathophysiological changes in degenerative joint diseases, such as osteoarthritis (OA) and intervertebral disc degeneration (IDD). A therapeutic role of HGF has been proposed in the regeneration of osteoarticular tissues. HGF also influences bone remodeling and peripheral nerve activity. Studies aimed at elucidating the changing role of HGF/c-Met signaling in OA and IDD at different pathophysiological stages, and their specific molecular mechanisms are needed. Such studies will contribute to safe and effective HGF/c-Met signaling-based treatments for OA and IDD. View Full-Text
Keywords: hepatocyte growth factor; osteoarthritis; intervertebral disc degeneration; articular cartilage; chondrocytes; nucleus pulposus cells; subchondral bone; vertebral endplate; peripheral nerve hepatocyte growth factor; osteoarthritis; intervertebral disc degeneration; articular cartilage; chondrocytes; nucleus pulposus cells; subchondral bone; vertebral endplate; peripheral nerve
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MDPI and ACS Style

Tonomura, H.; Nagae, M.; Takatori, R.; Ishibashi, H.; Itsuji, T.; Takahashi, K. The Potential Role of Hepatocyte Growth Factor in Degenerative Disorders of the Synovial Joint and Spine. Int. J. Mol. Sci. 2020, 21, 8717. https://doi.org/10.3390/ijms21228717

AMA Style

Tonomura H, Nagae M, Takatori R, Ishibashi H, Itsuji T, Takahashi K. The Potential Role of Hepatocyte Growth Factor in Degenerative Disorders of the Synovial Joint and Spine. International Journal of Molecular Sciences. 2020; 21(22):8717. https://doi.org/10.3390/ijms21228717

Chicago/Turabian Style

Tonomura, Hitoshi, Masateru Nagae, Ryota Takatori, Hidenobu Ishibashi, Tomonori Itsuji, and Kenji Takahashi. 2020. "The Potential Role of Hepatocyte Growth Factor in Degenerative Disorders of the Synovial Joint and Spine" International Journal of Molecular Sciences 21, no. 22: 8717. https://doi.org/10.3390/ijms21228717

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