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Review

Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut–Brain–Skin Axis

Department of Dermatology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon 21431, Korea
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(22), 8427; https://doi.org/10.3390/ijms21228427
Received: 29 September 2020 / Revised: 6 November 2020 / Accepted: 8 November 2020 / Published: 10 November 2020
(This article belongs to the Special Issue Inflammatory Skin Conditions 2020)
Rosacea is a common chronic cutaneous inflammatory disorder. Recently, patients with rosacea were identified as having a higher risk of developing various comorbidities such as cardiovascular disease, psychiatric disorders, neurologic disorders, and gastrointestinal disorders. However, the risks of some comorbidities in patients with rosacea are somewhat contradictory, depending upon the study design. Moreover, pathomechanisms associated with the comorbidities of patients with rosacea remain poorly elucidated. The purpose of this review was to provide the most up-to-date evidence on the risks of neuropsychiatric and gastrointestinal comorbidities in patients with rosacea. Moreover, the molecular pathomechanisms associated with neuropsychiatric and gastrointestinal comorbidities in patients with rosacea were evaluated based on recent studies. This review was also intended to focus more on the role of the gut–brain–skin axis in the association of neuropsychiatric and gastrointestinal comorbidities in rosacea. View Full-Text
Keywords: rosacea; comorbidity; psychiatric disorders; neurologic disorders; gastrointestinal disorders; risk rosacea; comorbidity; psychiatric disorders; neurologic disorders; gastrointestinal disorders; risk
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MDPI and ACS Style

Woo, Y.R.; Han, Y.J.; Kim, H.S.; Cho, S.H.; Lee, J.D. Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut–Brain–Skin Axis. Int. J. Mol. Sci. 2020, 21, 8427. https://doi.org/10.3390/ijms21228427

AMA Style

Woo YR, Han YJ, Kim HS, Cho SH, Lee JD. Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut–Brain–Skin Axis. International Journal of Molecular Sciences. 2020; 21(22):8427. https://doi.org/10.3390/ijms21228427

Chicago/Turabian Style

Woo, Yu R., Yu J. Han, Hei S. Kim, Sang H. Cho, and Jeong D. Lee. 2020. "Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut–Brain–Skin Axis" International Journal of Molecular Sciences 21, no. 22: 8427. https://doi.org/10.3390/ijms21228427

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