Ethanol Intoxication Alleviates the Inflammatory Response of Remote Organs to Experimental Traumatic Brain Injury
Abstract
:1. Introduction
2. Results
2.1. Ethanol Intoxication Downregulates TBI-Induced HMGB1, IL-6, and MMP9 but Enhances IL-1β Gene Expression in Liver Tissue
2.2. Ethanol Intoxication Modulates the Early Inflammatory Response in Liver Tissue upon TBI
2.3. Ethanol Intoxication Reduces the TBI-Induced Protein HMGB1 in Liver Tissue
2.4. Ethanol Intoxication Downregulates the TBI-Induced HMGB1, IL-6, IL-1β and TNF Gene Expression in Lungs
2.5. Elevation of IL-10 In Lung Tissue Early after Experimental TBI
3. Discussion
4. Materials and Methods
4.1. Animals and Experimental Model
4.2. Group Allocation
4.3. Quantification of Homogenate Protein Expression Levels by ELISA
4.4. Immunohistological Analysis of HMGB1
4.5. Statistical Analysis
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Xu, B.; Chandrasekar, A.; olde Heuvel, F.; Powerski, M.; Nowak, A.; Noack, L.; Omari, J.; Huber-Lang, M.; Roselli, F.; Relja, B. Ethanol Intoxication Alleviates the Inflammatory Response of Remote Organs to Experimental Traumatic Brain Injury. Int. J. Mol. Sci. 2020, 21, 8181. https://doi.org/10.3390/ijms21218181
Xu B, Chandrasekar A, olde Heuvel F, Powerski M, Nowak A, Noack L, Omari J, Huber-Lang M, Roselli F, Relja B. Ethanol Intoxication Alleviates the Inflammatory Response of Remote Organs to Experimental Traumatic Brain Injury. International Journal of Molecular Sciences. 2020; 21(21):8181. https://doi.org/10.3390/ijms21218181
Chicago/Turabian StyleXu, Baolin, Akila Chandrasekar, Florian olde Heuvel, Maciej Powerski, Aleksander Nowak, Laurens Noack, Jazan Omari, Markus Huber-Lang, Francesco Roselli, and Borna Relja. 2020. "Ethanol Intoxication Alleviates the Inflammatory Response of Remote Organs to Experimental Traumatic Brain Injury" International Journal of Molecular Sciences 21, no. 21: 8181. https://doi.org/10.3390/ijms21218181