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The Dual Role of Myeloperoxidase in Immune Response

Institute of Medical Physics and Biophysics, Medical Faculty, Leipzig University, 04 107 Leipzig, Germany
Int. J. Mol. Sci. 2020, 21(21), 8057; https://doi.org/10.3390/ijms21218057
Received: 5 October 2020 / Revised: 25 October 2020 / Accepted: 28 October 2020 / Published: 29 October 2020
(This article belongs to the Special Issue Role for the Enzyme Myeloperoxidase to Elicit Pathologies)
The heme protein myeloperoxidase (MPO) is a major constituent of neutrophils. As a key mediator of the innate immune system, neutrophils are rapidly recruited to inflammatory sites, where they recognize, phagocytose, and inactivate foreign microorganisms. In the newly formed phagosomes, MPO is involved in the creation and maintenance of an alkaline milieu, which is optimal in combatting microbes. Myeloperoxidase is also a key component in neutrophil extracellular traps. These helpful properties are contrasted by the release of MPO and other neutrophil constituents from necrotic cells or as a result of frustrated phagocytosis. Although MPO is inactivated by the plasma protein ceruloplasmin, it can interact with negatively charged components of serum and the extracellular matrix. In cardiovascular diseases and many other disease scenarios, active MPO and MPO-modified targets are present in atherosclerotic lesions and other disease-specific locations. This implies an involvement of neutrophils, MPO, and other neutrophil products in pathogenesis mechanisms. This review critically reflects on the beneficial and harmful functions of MPO against the background of immune response. View Full-Text
Keywords: myeloperoxidase; neutrophils; immune response; phagosomes; cardiovascular diseases; chronic inflammation myeloperoxidase; neutrophils; immune response; phagosomes; cardiovascular diseases; chronic inflammation
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MDPI and ACS Style

Arnhold, J. The Dual Role of Myeloperoxidase in Immune Response. Int. J. Mol. Sci. 2020, 21, 8057.

AMA Style

Arnhold J. The Dual Role of Myeloperoxidase in Immune Response. International Journal of Molecular Sciences. 2020; 21(21):8057.

Chicago/Turabian Style

Arnhold, Jürgen. 2020. "The Dual Role of Myeloperoxidase in Immune Response" Int. J. Mol. Sci. 21, no. 21: 8057.

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