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Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19

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Department of Cell Biology, Faculty of Science, Charles University, 120 00 Prague 2, Czech Republic
2
BIOCEV, Faculty of Science, Charles University, 252 50 Vestec, Czech Republic
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Centre for Tumour Ecology, First Faculty of Medicine, Charles University, 120 00 Prague 2, Czech Republic
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Department of Paediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital, 120 00 Prague, Czech Republic
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BIOCEV, First Faculty of Medicine, Charles University, 252 50 Vestec, Czech Republic
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Department of Analytical Chemistry, University of Chemistry and Technology Prague, 166 28 Praha 6, Czech Republic
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Laboratory of Genomics and Bioinformatics, Institute of Molecular Genetics, Czech Academy of Sciences, 140 00 Prague 4, Czech Republic
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Institute of Anatomy, Fist Faculty of Medicine, Charles University, 120 00 Prague 2, Czech Republic
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Department of Dermatovenereology, First Faculty of Medicine, Charles University and General University Hospital, 120 00 Prague 2, Czech Republic
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(21), 7937; https://doi.org/10.3390/ijms21217937
Received: 4 October 2020 / Revised: 19 October 2020 / Accepted: 21 October 2020 / Published: 26 October 2020
(This article belongs to the Special Issue Pharmacologic Targeting of the Tumor Microenvironment)
Interleukin-6 (IL-6) is a cytokine with multifaceted effects playing a remarkable role in the initiation of the immune response. The increased level of this cytokine in the elderly seems to be associated with the chronic inflammatory setting of the microenvironment in aged individuals. IL-6 also represents one of the main signals in communication between cancer cells and their non-malignant neighbours within the tumour niche. IL-6 also participates in the development of a premetastatic niche and in the adjustment of the metabolism in terminal-stage patients suffering from a malignant disease. IL-6 is a fundamental factor of the cytokine storm in patients with severe COVID-19, where it is responsible for the fatal outcome of the disease. A better understanding of the role of IL-6 under physiological as well as pathological conditions and the preparation of new strategies for the therapeutic control of the IL-6 axis may help to manage the problems associated with the elderly, cancer, and serious viral infections. View Full-Text
Keywords: tumour microenvironment; cancer ecosystem; ageing; COVID-19; IL-6; cytokine storm; cytokine; cancer-associated fibroblasts tumour microenvironment; cancer ecosystem; ageing; COVID-19; IL-6; cytokine storm; cytokine; cancer-associated fibroblasts
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MDPI and ACS Style

Brábek, J.; Jakubek, M.; Vellieux, F.; Novotný, J.; Kolář, M.; Lacina, L.; Szabo, P.; Strnadová, K.; Rösel, D.; Dvořánková, B.; Smetana, K., Jr. Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19. Int. J. Mol. Sci. 2020, 21, 7937.

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