Next Article in Journal
The Protective Effects of Pre- and Post-Administration of Micronized Palmitoylethanolamide Formulation on Postoperative Pain in Rats
Next Article in Special Issue
The Microenvironment of Decellularized Extracellular Matrix from Heart Failure Myocardium Alters the Balance between Angiogenic and Fibrotic Signals from Stromal Primitive Cells
Previous Article in Journal
The Human Digestive Tract Is Capable of Degrading Gluten from Birth
Previous Article in Special Issue
Cardiac Fibroblast-Induced Pluripotent Stem Cell-Derived Exosomes as a Potential Therapeutic Mean for Heart Failure
Open AccessReview

Cardiac Stem Cell-Loaded Delivery Systems: A New Challenge for Myocardial Tissue Regeneration

1
Department of Health Sciences, Magna Græcia University of Catanzaro, Loc. Germaneto, 88100 Catanzaro, Italy
2
Department of Experimental and Clinical Medicine, Magna Græcia University of Catanzaro, Loc. Germaneto, 88100 Catanzaro, Italy
3
Department of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, Loc. Germaneto, 88100 Catanzaro, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(20), 7701; https://doi.org/10.3390/ijms21207701
Received: 1 October 2020 / Revised: 13 October 2020 / Accepted: 16 October 2020 / Published: 18 October 2020
Cardiovascular disease (CVD) remains the leading cause of death in Western countries. Post-myocardial infarction heart failure can be considered a degenerative disease where myocyte loss outweighs any regenerative potential. In this scenario, regenerative biology and tissue engineering can provide effective solutions to repair the infarcted failing heart. The main strategies involve the use of stem and progenitor cells to regenerate/repair lost and dysfunctional tissue, administrated as a suspension or encapsulated in specific delivery systems. Several studies demonstrated that effectiveness of direct injection of cardiac stem cells (CSCs) is limited in humans by the hostile cardiac microenvironment and poor cell engraftment; therefore, the use of injectable hydrogel or pre-formed patches have been strongly advocated to obtain a better integration between delivered stem cells and host myocardial tissue. Several approaches were used to refine these types of constructs, trying to obtain an optimized functional scaffold. Despite the promising features of these stem cells’ delivery systems, few have reached the clinical practice. In this review, we summarize the advantages, and the novelty but also the current limitations of engineered patches and injectable hydrogels for tissue regenerative purposes, offering a perspective of how we believe tissue engineering should evolve to obtain the optimal delivery system applicable to the everyday clinical scenario. View Full-Text
Keywords: patches; injectable hydrogel; myocardial regeneration; nanomedicine; cardiac stem cell; tissue engineering patches; injectable hydrogel; myocardial regeneration; nanomedicine; cardiac stem cell; tissue engineering
Show Figures

Figure 1

MDPI and ACS Style

Mancuso, A.; Barone, A.; Cristiano, M.C.; Cianflone, E.; Fresta, M.; Paolino, D. Cardiac Stem Cell-Loaded Delivery Systems: A New Challenge for Myocardial Tissue Regeneration. Int. J. Mol. Sci. 2020, 21, 7701.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop