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Homocysteine and Mitochondria in Cardiovascular and Cerebrovascular Systems

Department of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius University in Bratislava, Mala Hora 4D, 036 01 Martin, Slovakia
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Int. J. Mol. Sci. 2020, 21(20), 7698; https://doi.org/10.3390/ijms21207698
Received: 2 October 2020 / Revised: 15 October 2020 / Accepted: 16 October 2020 / Published: 18 October 2020
(This article belongs to the Section Biochemistry)
Elevated concentration of homocysteine (Hcy) in the blood plasma, hyperhomocysteinemia (HHcy), has been implicated in various disorders, including cardiovascular and neurodegenerative diseases. Accumulating evidence indicates that pathophysiology of these diseases is linked with mitochondrial dysfunction. In this review, we discuss the current knowledge concerning the effects of HHcy on mitochondrial homeostasis, including energy metabolism, mitochondrial apoptotic pathway, and mitochondrial dynamics. The recent studies suggest that the interaction between Hcy and mitochondria is complex, and reactive oxygen species (ROS) are possible mediators of Hcy effects. We focus on mechanisms contributing to HHcy-associated oxidative stress, such as sources of ROS generation and alterations in antioxidant defense resulting from altered gene expression and post-translational modifications of proteins. Moreover, we discuss some recent findings suggesting that HHcy may have beneficial effects on mitochondrial ROS homeostasis and antioxidant defense. A better understanding of complex mechanisms through which Hcy affects mitochondrial functions could contribute to the development of more specific therapeutic strategies targeted at HHcy-associated disorders. View Full-Text
Keywords: homocysteine; hyperhomocysteinemia; mitochondria; heart; brain; oxidative stress; ROS homocysteine; hyperhomocysteinemia; mitochondria; heart; brain; oxidative stress; ROS
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MDPI and ACS Style

Kaplan, P.; Tatarkova, Z.; Sivonova, M.K.; Racay, P.; Lehotsky, J. Homocysteine and Mitochondria in Cardiovascular and Cerebrovascular Systems. Int. J. Mol. Sci. 2020, 21, 7698.

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