Next Article in Journal
Profiling of Tryptophan Metabolic Pathways in the Rat Fetoplacental Unit during Gestation
Previous Article in Journal
Mechanism and Function of the Catch State in Molluscan Smooth Muscle: A Historical Perspective
Previous Article in Special Issue
Selective Gold Recovery from Homogenous Aqueous Solutions Containing Gold and Platinum Ions by Aromatic Amino Acid-Containing Peptides
Open AccessReview

Current Progress in Cross-Linked Peptide Self-Assemblies

Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(20), 7577;
Received: 18 September 2020 / Revised: 6 October 2020 / Accepted: 9 October 2020 / Published: 14 October 2020
(This article belongs to the Special Issue Self-Assembly Mechanism and Connection of Peptides and Proteins)
Peptide-based fibrous supramolecular assemblies represent an emerging class of biomaterials that can realize various bioactivities and structures. Recently, a variety of peptide fibers with attractive functions have been designed together with the discovery of many peptide-based self-assembly units. Cross-linking of the peptide fibers is a key strategy to improve the functions of these materials. The cross-linking of peptide fibers forming three-dimensional networks in a dispersion can lead to changes in physical and chemical properties. Hydrogelation is a typical change caused by cross-linking, which makes it applicable to biomaterials such as cell scaffold materials. Cross-linking methods, which have been conventionally developed using water-soluble covalent polymers, are also useful in supramolecular peptide fibers. In the case of peptide fibers, unique cross-linking strategies can be designed by taking advantage of the functions of amino acids. This review focuses on the current progress in the design of cross-linked peptide fibers and their applications. View Full-Text
Keywords: self-assembly; peptide; cross-link; hydrogel; tissue engineering self-assembly; peptide; cross-link; hydrogel; tissue engineering
Show Figures

Figure 1

MDPI and ACS Style

Uchida, N.; Muraoka, T. Current Progress in Cross-Linked Peptide Self-Assemblies. Int. J. Mol. Sci. 2020, 21, 7577.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop